Jeffrey A. Engelman, et.al., Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers., Nature medicine, 2008, 14

http://rdf.ncbi.nlm.nih.gov/pubmed/19029981

Jeffrey A. Engelman, et.al., Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers., Nature medicine, 2008, 14

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-PIK3CA*H1047R)13Lca
  http://metadb.riken.jp/db/mgi_rdf/MGI:3834439

class

http://purl.org/net/cito/citesAsAuthority

• Tg(tetO-PIK3CA*H1047R)13Lca
  http://metadb.riken.jp/db/mgi_rdf/MGI:3834439

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased lung tumor incidence_Kras<tm4Tyj>/Kras<+>,Pik3r1<tm1Lca>/Pik3r1<+>,Pik3r2<tm1Lca>/Pik3r2<tm1Lca>
  http://metadb.riken.jp/0008014I129S4SvJae129S6SvEvTacKrastm4TyjKrasPik3r1tm1LcaPik3r1Pik3r2tm1LcaPik3r2tm1LcaPik3r1tm1LcaPik3r1Krastm4TyjKrasPik3r2tm1Lca
• increased lung tumor incidence_Kras<tm4Tyj>/Kras<+>,Pik3r2<tm1Lca>/Pik3r2<tm1Lca>
  http://metadb.riken.jp/0008014I129S4SvJae129S6SvEvTacKrastm4TyjKrasPik3r2tm1LcaPik3r2tm1LcaKrastm4TyjPik3r2tm1LcaKras
• increased lung adenocarcinoma incidence_Tg(Scgb1a1-rtTA)1Jaw/0,Tg(tetO-PIK3CA*H1047R)13Lca/0
  http://metadb.riken.jp/0002027I129C57BL6FVBNTgScgb1a1rtTA1Jaw0TgtetOPIK3CAH1047R13Lca0TgtetOPIK3CAH1047R13LcaTgScgb1a1rtTA1Jaw
• decreased lung tumor incidence_Kras<tm4Tyj>/Kras<+>,Pik3r1<tm1Lca>/Pik3r1<tm1Lca>,Pik3r2<tm1Lca>/Pik3r2<tm1Lca>
  http://metadb.riken.jp/0010267I129S4SvJae129S6SvEvTacKrastm4TyjKrasPik3r1tm1LcaPik3r1tm1LcaPik3r2tm1LcaPik3r2tm1LcaKrastm4TyjPik3r2tm1LcaKrasPik3r1tm1Lca