abnormal CD4-positive T cell differentiation_Socs1<tm1Ayos>/Socs1<tm1Ayos>,Tg(Lck-cre)1Jtak/0

http://metadb.riken.jp/0008076I129S4SvJaeC57BL6Socs1tm1AyosSocs1tm1AyosTgLckcre1Jtak0Socs1tm1AyosTgLckcre1Jtak

abnormal CD4-positive T cell differentiation_Socs1<tm1Ayos>/Socs1<tm1Ayos>,Tg(Lck-cre)1Jtak/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• suppressor of cytokine signaling 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1354910
• transgene insertion 1, Junji Takeda
  http://metadb.riken.jp/db/mgi_rdf/MGI:3655253

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Socs1<tm1Ayos>/Socs1<tm1Ayos>,Tg(Lck-cre)1Jtak/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Socs1<tm1Ayos>|Tg(Lck-cre)1Jtak

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal CD4-positive T cell differentiation
  http://purl.obolibrary.org/obo/MP_0008076

文献

http://purl.org/net/cito/citesAsAuthority

• Kentaro. Tanaka, et.al., Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads., Journal of immunology (Baltimore, Md. : 1950), 2008, 180
  http://rdf.ncbi.nlm.nih.gov/pubmed/18322180