Kentaro. Tanaka, et.al., Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads., Journal of immunology (Baltimore, Md. : 1950), 2008, 180

http://rdf.ncbi.nlm.nih.gov/pubmed/18322180

Kentaro. Tanaka, et.al., Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads., Journal of immunology (Baltimore, Md. : 1950), 2008, 180

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Socs1<tm1Ayos>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3778686

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal CD4-positive, alpha-beta T cell physiology_Socs1<tm1Ayos>/Socs1<tm1Ayos>,Tg(Lck-cre)1Jtak/0
  http://metadb.riken.jp/0005463I129S4SvJaeC57BL6Socs1tm1AyosSocs1tm1AyosTgLckcre1Jtak0Socs1tm1AyosTgLckcre1Jtak
• increased interleukin-17 secretion_Ifng<tm1Ts>/Ifng<tm1Ts>
  http://metadb.riken.jp/0008681I129S7SvEvBrdIfngtm1TsIfngtm1TsIfngtm1Ts
• decreased susceptibility to experimental autoimmune encephalomyelitis_Socs1<tm1Ayos>/Socs1<tm1Ayos>,Tg(Lck-cre)1Jtak/0
  http://metadb.riken.jp/0004800I129S4SvJaeC57BL6Socs1tm1AyosSocs1tm1AyosTgLckcre1Jtak0Socs1tm1AyosTgLckcre1Jtak
• increased interleukin-17 secretion_Ifng<tm1Ts>/Ifng<tm1Ts>,Socs1<tm1Jni>/Socs1<tm1Jni>
  http://metadb.riken.jp/0008681I129S7SvEvBrdIfngtm1TsIfngtm1TsSocs1tm1JniSocs1tm1JniIfngtm1TsSocs1tm1Jni
• increased CD8-positive, alpha-beta T cell number_Socs1<tm1Ayos>/Socs1<tm1Ayos>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0008078I129S4SvJaeC57BL6SJLSocs1tm1AyosSocs1tm1AyosTgTekcre1Ywa0TgTekcre1YwaSocs1tm1Ayos
• abnormal CD4-positive T cell differentiation_Socs1<tm1Ayos>/Socs1<tm1Ayos>,Tg(Lck-cre)1Jtak/0
  http://metadb.riken.jp/0008076I129S4SvJaeC57BL6Socs1tm1AyosSocs1tm1AyosTgLckcre1Jtak0Socs1tm1AyosTgLckcre1Jtak
• decreased CD4-positive, alpha beta T cell number_Socs1<tm1Ayos>/Socs1<tm1Ayos>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0008075I129S4SvJaeC57BL6SJLSocs1tm1AyosSocs1tm1AyosTgTekcre1Ywa0TgTekcre1YwaSocs1tm1Ayos
• no abnormal phenotype detected_Socs1<tm1Ayos>/Socs1<tm1Ayos>
  http://metadb.riken.jp/0002169I129S4SvJaeC57BL6Socs1tm1AyosSocs1tm1AyosSocs1tm1Ayos
• decreased susceptibility to experimental autoimmune encephalomyelitis_Tg(Lck-Socs3)1Kubo/0
  http://metadb.riken.jp/0004800NSTgLckSocs31Kubo0TgLckSocs31Kubo
• premature death_Socs1<tm1Ayos>/Socs1<tm1Ayos>,Tg(Tek-cre)1Ywa/0
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6SJLSocs1tm1AyosSocs1tm1AyosTgTekcre1Ywa0TgTekcre1YwaSocs1tm1Ayos
• abnormal CD4-positive T cell differentiation_Tg(Lck-Socs3)1Kubo/0
  http://metadb.riken.jp/0008076NSTgLckSocs31Kubo0TgLckSocs31Kubo

class

http://purl.org/net/cito/citesAsAuthority

• Socs1<tm1Ayos>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3778686

article

http://www.w3.org/2000/01/rdf-schema#seeAlso

• [Blank]
• [Blank]

BRC マウスの系統

http://purl.org/net/cito/citesAsAuthority

• B6;129S4(Cg)-Socs1<tm1Ayos>
  http://metadb.riken.jp/db/rikenbrc_mouse/RBRC04753
• B6.Cg-Tg(Lck-cre)1Jtak
  http://metadb.riken.jp/db/rikenbrc_mouse/RBRC04738

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• premature death in RBRC04753
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015420
• increased CD8-positive, alpha-beta T cell number in RBRC04753
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015422
• abnormal CD4-positive, alpha-beta T cell physiology in RBRC04753
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015418
• no abnormal phenotype detected in RBRC04753
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1006858
• abnormal CD4-positive T cell differentiation in RBRC04753
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015417
• decreased susceptibility to experimental autoimmune encephalomyelitis in RBRC04753
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015419
• decreased CD4-positive, alpha beta T cell number in RBRC04753
  http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015421

article

http://www.w3.org/2000/01/rdf-schema#seeAlso

• [Blank]
• [Blank]