decreased CD8-positive, alpha-beta T cell number_Grb2<tm1.1Hua>/Grb2<tm1.1Hua>,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0

http://metadb.riken.jp/0008079I129C57BL6C57BL6JDBA2JGrb2tm11HuaGrb2tm11HuaTgLckcre1Jtak0TgTcraHYTcrbHY71Vbo0Grb2tm11HuaTgTcraHYTcrbHY71VboTgLckcre1Jtak

decreased CD8-positive, alpha-beta T cell number_Grb2<tm1.1Hua>/Grb2<tm1.1Hua>,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• growth factor receptor bound protein 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:95805
• transgene insertion 1, Junji Takeda
  http://metadb.riken.jp/db/mgi_rdf/MGI:3655253
• transgene insertion 71, Harald von Boehmer
  http://metadb.riken.jp/db/mgi_rdf/MGI:3044559

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Grb2<tm1.1Hua>/Grb2<tm1.1Hua>,Tg(Lck-cre)1Jtak/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Grb2<tm1.1Hua>|Tg(TcraH-Y,TcrbH-Y)71Vbo|Tg(Lck-cre)1Jtak

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6 * C57BL/6J * DBA/2J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased CD8-positive, alpha-beta T cell number
  http://purl.obolibrary.org/obo/MP_0008079

文献

http://purl.org/net/cito/citesAsAuthority

• Ihn Kyung. Jang, et.al., Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107
  http://rdf.ncbi.nlm.nih.gov/pubmed/20498059