increased T-helper 1 cell number_Tgfb1<tm3.1Flv>/Tgfb1<tm3.1Flv>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0

http://metadb.riken.jp/0008086I129C57BL6DBA2NODSJLTgfb1tm31FlvTgfb1tm31FlvTgCd4cre1Cwi0TgTcraBDC25TcrbBDC251Doi0Tgfb1tm31FlvTgCd4cre1CwiTgTcraBDC25TcrbBDC251Doi

increased T-helper 1 cell number_Tgfb1<tm3.1Flv>/Tgfb1<tm3.1Flv>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transforming growth factor, beta 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:98725
• transgene insertion 1, Christophe Benoist
  http://metadb.riken.jp/db/mgi_rdf/MGI:3612117
• transgene insertion 1, Christopher B Wilson
  http://metadb.riken.jp/db/mgi_rdf/MGI:2448688

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tgfb1<tm3.1Flv>/Tgfb1<tm3.1Flv>,Tg(Cd4-cre)1Cwi/0,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tgfb1<tm3.1Flv>|Tg(Cd4-cre)1Cwi|Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6 * DBA/2 * NOD * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased T-helper 1 cell number
  http://purl.obolibrary.org/obo/MP_0008086

文献

http://purl.org/net/cito/citesAsAuthority

• Harumichi. Ishigame, et.al., Excessive Th1 responses due to the absence of TGF-β signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110
  http://rdf.ncbi.nlm.nih.gov/pubmed/23569233