increased dendritic cell number_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0

http://metadb.riken.jp/0008126I129P2OlaHsdC57BL6CBALyntm11CaloLyntm11CaloTgItgaxcre11Reiz0Lyntm11CaloTgItgaxcre11Reiz

increased dendritic cell number_Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1-1, Boris Reizis
  http://metadb.riken.jp/db/mgi_rdf/MGI:3763247
• LYN proto-oncogene, Src family tyrosine kinase
  http://metadb.riken.jp/db/mgi_rdf/MGI:96892

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Lyn<tm1.1Calo>/Lyn<tm1.1Calo>,Tg(Itgax-cre)1-1Reiz/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Lyn<tm1.1Calo>|Tg(Itgax-cre)1-1Reiz

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased dendritic cell number
  http://purl.obolibrary.org/obo/MP_0008126

文献

http://purl.org/net/cito/citesAsAuthority

• Chrystelle. Lamagna, et.al., Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110
  http://rdf.ncbi.nlm.nih.gov/pubmed/23940344