decreased follicular B cell number_Cd74<tm1Liz>/Cd74<tm1Liz>,Sppl2a<tm1Dgen>/Sppl2a<tm1Dgen>

http://metadb.riken.jp/0008174I129P2OlaHsd129SSvEvC57BL6Cd74tm1LizCd74tm1LizSppl2atm1DgenSppl2atm1DgenCd74tm1LizSppl2atm1Dgen

decreased follicular B cell number_Cd74<tm1Liz>/Cd74<tm1Liz>,Sppl2a<tm1Dgen>/Sppl2a<tm1Dgen>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• signal peptide peptidase like 2A
  http://metadb.riken.jp/db/mgi_rdf/MGI:1913802
• CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
  http://metadb.riken.jp/db/mgi_rdf/MGI:96534

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cd74<tm1Liz>/Cd74<tm1Liz>,Sppl2a<tm1Dgen>/Sppl2a<tm1Dgen>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cd74<tm1Liz>|Sppl2a<tm1Dgen>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased follicular B cell number
  http://purl.obolibrary.org/obo/MP_0008174

文献

http://purl.org/net/cito/citesAsAuthority

• Daniel R. Beisner, et.al., The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain., The Journal of experimental medicine, 2013, 210
  http://rdf.ncbi.nlm.nih.gov/pubmed/23267013