Daniel R. Beisner, et.al., The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain., The Journal of experimental medicine, 2013, 210

http://rdf.ncbi.nlm.nih.gov/pubmed/23267013

Daniel R. Beisner, et.al., The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain., The Journal of experimental medicine, 2013, 210

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Sppl2a<chompB>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5484577
• Sppl2a<tm1Dgen>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5484576

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal class switch recombination_Sppl2a<chompB>/Sppl2a<chompB>
  http://metadb.riken.jp/0004816IC57BL6Sppl2achompBSppl2achompBSppl2achompB
• decreased activation-induced B cell apoptosis_Sppl2a<chompB>/Sppl2a<chompB>
  http://metadb.riken.jp/0010675IC57BL6Sppl2achompBSppl2achompBSppl2achompB
• decreased IgM level_Sppl2a<tm1Dgen>/Sppl2a<tm1Dgen>
  http://metadb.riken.jp/0001806B6129P2Sppl2atm1DgenSppl2atm1DgenSppl2atm1DgenSppl2atm1Dgen
• decreased myeloid dendritic cell number_Sppl2a<tm1Dgen>/Sppl2a<tm1Dgen>
  http://metadb.riken.jp/0008122B6129P2Sppl2atm1DgenSppl2atm1DgenSppl2atm1DgenSppl2atm1Dgen
• decreased transitional stage T2 B cell number_Sppl2a<tm1Dgen>/Sppl2a<tm1Dgen>
  http://metadb.riken.jp/0009926B6129P2Sppl2atm1DgenSppl2atm1DgenSppl2atm1DgenSppl2atm1Dgen
• decreased IgG3 level_Sppl2a<tm1Dgen>/Sppl2a<tm1Dgen>
  http://metadb.riken.jp/0008498B6129P2Sppl2atm1DgenSppl2atm1DgenSppl2atm1DgenSppl2atm1Dgen
• decreased mature B cell number_Sppl2a<chompB>/Sppl2a<chompB>
  http://metadb.riken.jp/0008211IC57BL6Sppl2achompBSppl2achompBSppl2achompB
• decreased IgG1 level_Sppl2a<chompB>/Sppl2a<chompB>
  http://metadb.riken.jp/0008495IC57BL6Sppl2achompBSppl2achompBSppl2achompB
• decreased plasmacytoid dendritic cell number_Sppl2a<chompB>/Sppl2a<chompB>
  http://metadb.riken.jp/0008124IC57BL6Sppl2achompBSppl2achompBSppl2achompB
• decreased B-1 B cell number_Sppl2a<tm1Dgen>/Sppl2a<tm1Dgen>
  http://metadb.riken.jp/0004978B6129P2Sppl2atm1DgenSppl2atm1DgenSppl2atm1DgenSppl2atm1Dgen
• decreased B cell proliferation_Sppl2a<chompB>/Sppl2a<chompB>
  http://metadb.riken.jp/0005093IC57BL6Sppl2achompBSppl2achompBSppl2achompB
• decreased IgG2b level_Sppl2a<chompB>/Sppl2a<chompB>
  http://metadb.riken.jp/0008497IC57BL6Sppl2achompBSppl2achompBSppl2achompB
• decreased myeloid dendritic cell number_Sppl2a<chompB>/Sppl2a<chompB>
  http://metadb.riken.jp/0008122IC57BL6Sppl2achompBSppl2achompBSppl2achompB
• decreased IgG2b level_Sppl2a<tm1Dgen>/Sppl2a<tm1Dgen>
  http://metadb.riken.jp/0008497B6129P2Sppl2atm1DgenSppl2atm1DgenSppl2atm1DgenSppl2atm1Dgen
• decreased IgG3 level_Sppl2a<chompB>/Sppl2a<chompB>
  http://metadb.riken.jp/0008498IC57BL6Sppl2achompBSppl2achompBSppl2achompB
• decreased IgM level_Sppl2a<chompB>/Sppl2a<chompB>
  http://metadb.riken.jp/0001806IC57BL6Sppl2achompBSppl2achompBSppl2achompB
• decreased transitional stage T2 B cell number_Sppl2a<chompB>/Sppl2a<chompB>
  http://metadb.riken.jp/0009926IC57BL6Sppl2achompBSppl2achompBSppl2achompB
• decreased IgA level_Sppl2a<tm1Dgen>/Sppl2a<tm1Dgen>
  http://metadb.riken.jp/0001807B6129P2Sppl2atm1DgenSppl2atm1DgenSppl2atm1DgenSppl2atm1Dgen
• decreased IgG1 level_Sppl2a<tm1Dgen>/Sppl2a<tm1Dgen>
  http://metadb.riken.jp/0008495B6129P2Sppl2atm1DgenSppl2atm1DgenSppl2atm1DgenSppl2atm1Dgen
• decreased marginal zone B cell number_Sppl2a<chompB>/Sppl2a<chompB>
  http://metadb.riken.jp/0008182IC57BL6Sppl2achompBSppl2achompBSppl2achompB
• decreased B cell number_Sppl2a<tm1Dgen>/Sppl2a<tm1Dgen>
  http://metadb.riken.jp/0005017B6129P2Sppl2atm1DgenSppl2atm1DgenSppl2atm1DgenSppl2atm1Dgen
• decreased follicular B cell number_Sppl2a<tm1Dgen>/Sppl2a<tm1Dgen>
  http://metadb.riken.jp/0008174B6129P2Sppl2atm1DgenSppl2atm1DgenSppl2atm1DgenSppl2atm1Dgen
• decreased follicular B cell number_Sppl2a<chompB>/Sppl2a<chompB>
  http://metadb.riken.jp/0008174IC57BL6Sppl2achompBSppl2achompBSppl2achompB
• abnormal humoral immune response_Sppl2a<chompB>/Sppl2a<chompB>
  http://metadb.riken.jp/0001800IC57BL6Sppl2achompBSppl2achompBSppl2achompB
• decreased follicular B cell number_Cd74<tm1Liz>/Cd74<tm1Liz>,Sppl2a<tm1Dgen>/Sppl2a<tm1Dgen>
  http://metadb.riken.jp/0008174I129P2OlaHsd129SSvEvC57BL6Cd74tm1LizCd74tm1LizSppl2atm1DgenSppl2atm1DgenCd74tm1LizSppl2atm1Dgen

class

http://purl.org/net/cito/citesAsAuthority

• Sppl2a<chompB>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5484577
• Sppl2a<tm1Dgen>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5484576