increased germinal center B cell number_Col1a1<tm1(CAG-Ezh2*)Meln>/Col1a1<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>

http://metadb.riken.jp/0008177I129P2OlaHsd129S4SvJaeC57BL6Col1a1tm1CAGEzh2MelnCol1a1Ighg1tm1creCgnIghg1Col1a1Ighg1Col1a1tm1CAGEzh2MelnIghg1tm1creCgn

increased germinal center B cell number_Col1a1<tm1(CAG-Ezh2*)Meln>/Col1a1<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• collagen, type I, alpha 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88467
• immunoglobulin heavy constant gamma 1 (G1m marker)
  http://metadb.riken.jp/db/mgi_rdf/MGI:96446

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Col1a1<tm1(CAG-Ezh2*)Meln>/Col1a1<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Col1a1<+>|Ighg1<+>|Col1a1<tm1(CAG-Ezh2*)Meln>|Ighg1<tm1(cre)Cgn>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased germinal center B cell number
  http://purl.obolibrary.org/obo/MP_0008177

文献

http://purl.org/net/cito/citesAsAuthority

• Wendy. Béguelin, et.al., EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation., Cancer cell, 2013, 23
  http://rdf.ncbi.nlm.nih.gov/pubmed/23680150