Wendy. Béguelin, et.al., EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation., Cancer cell, 2013, 23

http://rdf.ncbi.nlm.nih.gov/pubmed/23680150

Wendy. Béguelin, et.al., EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation., Cancer cell, 2013, 23

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm1(CAG-Ezh2*)Meln>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5519911

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased IgG3 level_Ezh2<tm1Tara>/Ezh2<tm1Tara>,Ighg1<tm1(cre)Cgn>/Ighg1<+>
  http://metadb.riken.jp/0008498I129P2OlaHsdEzh2tm1TaraEzh2tm1TaraIghg1tm1creCgnIghg1Ezh2tm1TaraIghg1Ighg1tm1creCgn
• decreased spleen germinal center size_Ezh2<tm1Tara>/Ezh2<tm1Tara>,Ighg1<tm1(cre)Cgn>/Ighg1<+>
  http://metadb.riken.jp/0008484I129P2OlaHsdEzh2tm1TaraEzh2tm1TaraIghg1tm1creCgnIghg1Ezh2tm1TaraIghg1Ighg1tm1creCgn
• decreased spleen germinal center number_Ezh2<tm1Tara>/Ezh2<tm1Tara>,Ighg1<tm1(cre)Cgn>/Ighg1<+>
  http://metadb.riken.jp/0008482I129P2OlaHsdEzh2tm1TaraEzh2tm1TaraIghg1tm1creCgnIghg1Ezh2tm1TaraIghg1Ighg1tm1creCgn
• decreased IgG1 level_Ezh2<tm1Tara>/Ezh2<tm1Tara>,Ighg1<tm1(cre)Cgn>/Ighg1<+>
  http://metadb.riken.jp/0008495I129P2OlaHsdEzh2tm1TaraEzh2tm1TaraIghg1tm1creCgnIghg1Ezh2tm1TaraIghg1Ighg1tm1creCgn
• decreased germinal center B cell number_Ezh2<tm1Tara>/Ezh2<tm1Tara>,Ighg1<tm1(cre)Cgn>/Ighg1<+>
  http://metadb.riken.jp/0008178I129P2OlaHsdEzh2tm1TaraEzh2tm1TaraIghg1tm1creCgnIghg1Ezh2tm1TaraIghg1Ighg1tm1creCgn
• decreased B cell proliferation_Ezh2<tm1Tara>/Ezh2<tm1Tara>,Ighg1<tm1(cre)Cgn>/Ighg1<+>
  http://metadb.riken.jp/0005093I129P2OlaHsdEzh2tm1TaraEzh2tm1TaraIghg1tm1creCgnIghg1Ezh2tm1TaraIghg1Ighg1tm1creCgn
• increased germinal center B cell number_Col1a1<tm1(CAG-Ezh2*)Meln>/Col1a1<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>
  http://metadb.riken.jp/0008177I129P2OlaHsd129S4SvJaeC57BL6Col1a1tm1CAGEzh2MelnCol1a1Ighg1tm1creCgnIghg1Col1a1Ighg1Col1a1tm1CAGEzh2MelnIghg1tm1creCgn
• decreased IgG2b level_Ezh2<tm1Tara>/Ezh2<tm1Tara>,Ighg1<tm1(cre)Cgn>/Ighg1<+>
  http://metadb.riken.jp/0008497I129P2OlaHsdEzh2tm1TaraEzh2tm1TaraIghg1tm1creCgnIghg1Ezh2tm1TaraIghg1Ighg1tm1creCgn
• increased spleen germinal center size_Col1a1<tm1(CAG-Ezh2*)Meln>/Col1a1<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>
  http://metadb.riken.jp/0008483I129P2OlaHsd129S4SvJaeC57BL6Col1a1tm1CAGEzh2MelnCol1a1Ighg1tm1creCgnIghg1Col1a1Ighg1Col1a1tm1CAGEzh2MelnIghg1tm1creCgn
• increased spleen germinal center number_Col1a1<tm1(CAG-Ezh2*)Meln>/Col1a1<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>
  http://metadb.riken.jp/0008481I129P2OlaHsd129S4SvJaeC57BL6Col1a1tm1CAGEzh2MelnCol1a1Ighg1tm1creCgnIghg1Col1a1Ighg1Col1a1tm1CAGEzh2MelnIghg1tm1creCgn

class

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm1(CAG-Ezh2*)Meln>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5519911