abnormal germinal center B cell physiology_Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Prdm1<tm2Masu>/Prdm1<tm2Masu>

http://metadb.riken.jp/0008192I129P2OlaHsdC57BL6GtROSA26Sortm4IkbkbRskyGtROSA26SorIghg1tm1creCgnIghg1Prdm1tm2MasuPrdm1tm2MasuPrdm1tm2MasuGtROSA26Sortm4IkbkbRskyGtROSA26SorIghg1Ighg1tm1creCgn

abnormal germinal center B cell physiology_Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Prdm1<tm2Masu>/Prdm1<tm2Masu>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• PR domain containing 1, with ZNF domain
  http://metadb.riken.jp/db/mgi_rdf/MGI:99655
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• immunoglobulin heavy constant gamma 1 (G1m marker)
  http://metadb.riken.jp/db/mgi_rdf/MGI:96446

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Prdm1<tm2Masu>/Prdm1<tm2Masu>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Prdm1<tm2Masu>|Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>|Gt(ROSA)26Sor<+>|Ighg1<+>|Ighg1<tm1(cre)Cgn>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal germinal center B cell physiology
  http://purl.obolibrary.org/obo/MP_0008192

文献

http://purl.org/net/cito/citesAsAuthority

• Dinis Pedro. Calado, et.al., Constitutive canonical NF-κB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma., Cancer cell, 2010, 18
  http://rdf.ncbi.nlm.nih.gov/pubmed/21156282