Dinis Pedro. Calado, et.al., Constitutive canonical NF-κB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma., Cancer cell, 2010, 18

http://rdf.ncbi.nlm.nih.gov/pubmed/21156282

Dinis Pedro. Calado, et.al., Constitutive canonical NF-κB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma., Cancer cell, 2010, 18

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased germinal center B cell number_Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>
  http://metadb.riken.jp/0008178I129P2OlaHsdC57BL6GtROSA26Sortm4IkbkbRskyGtROSA26SorIghg1tm1creCgnIghg1Ighg1tm1creCgnIghg1GtROSA26Sortm4IkbkbRskyGtROSA26Sor
• premature death_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Prdm1<tm2Masu>/Prdm1<tm2Masu>
  http://metadb.riken.jp/0002083I129P2OlaHsd129X1SvJGtROSA26Sortm1EYFPCosGtROSA26SorIghg1tm1creCgnIghg1Prdm1tm2MasuPrdm1tm2MasuIghg1tm1creCgnGtROSA26Sortm1EYFPCosIghg1GtROSA26SorPrdm1tm2Masu
• increased germinal center B cell number_Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Prdm1<tm2Masu>/Prdm1<tm2Masu>
  http://metadb.riken.jp/0008177I129P2OlaHsdC57BL6GtROSA26Sortm4IkbkbRskyGtROSA26SorIghg1tm1creCgnIghg1Prdm1tm2MasuPrdm1tm2MasuPrdm1tm2MasuGtROSA26Sortm4IkbkbRskyGtROSA26SorIghg1Ighg1tm1creCgn
• abnormal spleen morphology_Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>
  http://metadb.riken.jp/0000689I129P2OlaHsdC57BL6GtROSA26Sortm4IkbkbRskyGtROSA26SorIghg1tm1creCgnIghg1Ighg1tm1creCgnIghg1GtROSA26Sortm4IkbkbRskyGtROSA26Sor
• abnormal germinal center B cell physiology_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Prdm1<tm2Masu>/Prdm1<tm2Masu>
  http://metadb.riken.jp/0008192I129P2OlaHsd129X1SvJGtROSA26Sortm1EYFPCosGtROSA26SorIghg1tm1creCgnIghg1Prdm1tm2MasuPrdm1tm2MasuIghg1tm1creCgnGtROSA26Sortm1EYFPCosIghg1GtROSA26SorPrdm1tm2Masu
• decreased IgG1 level_Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Prdm1<tm2Masu>/Prdm1<tm2Masu>
  http://metadb.riken.jp/0008495I129P2OlaHsdC57BL6GtROSA26Sortm4IkbkbRskyGtROSA26SorIghg1tm1creCgnIghg1Prdm1tm2MasuPrdm1tm2MasuPrdm1tm2MasuGtROSA26Sortm4IkbkbRskyGtROSA26SorIghg1Ighg1tm1creCgn
• decreased survivor rate_Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Prdm1<tm2Masu>/Prdm1<tm2Masu>
  http://metadb.riken.jp/0008770I129P2OlaHsdC57BL6GtROSA26Sortm4IkbkbRskyGtROSA26SorIghg1tm1creCgnIghg1Prdm1tm2MasuPrdm1tm2MasuPrdm1tm2MasuGtROSA26Sortm4IkbkbRskyGtROSA26SorIghg1Ighg1tm1creCgn
• increased B cell derived lymphoma incidence_Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Prdm1<tm2Masu>/Prdm1<tm2Masu>
  http://metadb.riken.jp/0002023I129P2OlaHsdC57BL6GtROSA26Sortm4IkbkbRskyGtROSA26SorIghg1tm1creCgnIghg1Prdm1tm2MasuPrdm1tm2MasuPrdm1tm2MasuGtROSA26Sortm4IkbkbRskyGtROSA26SorIghg1Ighg1tm1creCgn
• increased B cell number_Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>
  http://metadb.riken.jp/0005014I129P2OlaHsdC57BL6GtROSA26Sortm4IkbkbRskyGtROSA26SorIghg1tm1creCgnIghg1Ighg1tm1creCgnIghg1GtROSA26Sortm4IkbkbRskyGtROSA26Sor
• premature death_Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Prdm1<tm2Masu>/Prdm1<tm2Masu>
  http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6GtROSA26Sortm4IkbkbRskyGtROSA26SorIghg1tm1creCgnIghg1Prdm1tm2MasuPrdm1tm2MasuPrdm1tm2MasuGtROSA26Sortm4IkbkbRskyGtROSA26SorIghg1Ighg1tm1creCgn
• enlarged liver_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Prdm1<tm2Masu>/Prdm1<tm2Masu>
  http://metadb.riken.jp/0000599I129P2OlaHsd129X1SvJGtROSA26Sortm1EYFPCosGtROSA26SorIghg1tm1creCgnIghg1Prdm1tm2MasuPrdm1tm2MasuIghg1tm1creCgnGtROSA26Sortm1EYFPCosIghg1GtROSA26SorPrdm1tm2Masu
• increased B cell derived lymphoma incidence_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Prdm1<tm2Masu>/Prdm1<tm2Masu>
  http://metadb.riken.jp/0002023I129P2OlaHsd129X1SvJGtROSA26Sortm1EYFPCosGtROSA26SorIghg1tm1creCgnIghg1Prdm1tm2MasuPrdm1tm2MasuIghg1tm1creCgnGtROSA26Sortm1EYFPCosIghg1GtROSA26SorPrdm1tm2Masu
• enlarged spleen_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Prdm1<tm2Masu>/Prdm1<tm2Masu>
  http://metadb.riken.jp/0000691I129P2OlaHsd129X1SvJGtROSA26Sortm1EYFPCosGtROSA26SorIghg1tm1creCgnIghg1Prdm1tm2MasuPrdm1tm2MasuIghg1tm1creCgnGtROSA26Sortm1EYFPCosIghg1GtROSA26SorPrdm1tm2Masu
• decreased IgG1 level_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Prdm1<tm2Masu>/Prdm1<tm2Masu>
  http://metadb.riken.jp/0008495I129P2OlaHsd129X1SvJGtROSA26Sortm1EYFPCosGtROSA26SorIghg1tm1creCgnIghg1Prdm1tm2MasuPrdm1tm2MasuIghg1tm1creCgnGtROSA26Sortm1EYFPCosIghg1GtROSA26SorPrdm1tm2Masu
• increased IgG1 level_Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>
  http://metadb.riken.jp/0008499I129P2OlaHsdC57BL6GtROSA26Sortm4IkbkbRskyGtROSA26SorIghg1tm1creCgnIghg1Ighg1tm1creCgnIghg1GtROSA26Sortm4IkbkbRskyGtROSA26Sor
• abnormal plasma cell differentiation_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Prdm1<tm2Masu>/Prdm1<tm2Masu>
  http://metadb.riken.jp/0008099I129P2OlaHsd129X1SvJGtROSA26Sortm1EYFPCosGtROSA26SorIghg1tm1creCgnIghg1Prdm1tm2MasuPrdm1tm2MasuIghg1tm1creCgnGtROSA26Sortm1EYFPCosIghg1GtROSA26SorPrdm1tm2Masu
• increased IgM level_Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>
  http://metadb.riken.jp/0002494I129P2OlaHsdC57BL6GtROSA26Sortm4IkbkbRskyGtROSA26SorIghg1tm1creCgnIghg1Ighg1tm1creCgnIghg1GtROSA26Sortm4IkbkbRskyGtROSA26Sor
• increased germinal center B cell number_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Prdm1<tm2Masu>/Prdm1<tm2Masu>
  http://metadb.riken.jp/0008177I129P2OlaHsd129X1SvJGtROSA26Sortm1EYFPCosGtROSA26SorIghg1tm1creCgnIghg1Prdm1tm2MasuPrdm1tm2MasuIghg1tm1creCgnGtROSA26Sortm1EYFPCosIghg1GtROSA26SorPrdm1tm2Masu
• decreased survivor rate_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Prdm1<tm2Masu>/Prdm1<tm2Masu>
  http://metadb.riken.jp/0008770I129P2OlaHsd129X1SvJGtROSA26Sortm1EYFPCosGtROSA26SorIghg1tm1creCgnIghg1Prdm1tm2MasuPrdm1tm2MasuIghg1tm1creCgnGtROSA26Sortm1EYFPCosIghg1GtROSA26SorPrdm1tm2Masu
• abnormal plasma cell differentiation_Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Prdm1<tm2Masu>/Prdm1<tm2Masu>
  http://metadb.riken.jp/0008099I129P2OlaHsdC57BL6GtROSA26Sortm4IkbkbRskyGtROSA26SorIghg1tm1creCgnIghg1Prdm1tm2MasuPrdm1tm2MasuPrdm1tm2MasuGtROSA26Sortm4IkbkbRskyGtROSA26SorIghg1Ighg1tm1creCgn
• increased plasma cell number_Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>
  http://metadb.riken.jp/0008097I129P2OlaHsdC57BL6GtROSA26Sortm4IkbkbRskyGtROSA26SorIghg1tm1creCgnIghg1Ighg1tm1creCgnIghg1GtROSA26Sortm4IkbkbRskyGtROSA26Sor
• enlarged lymph nodes_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Prdm1<tm2Masu>/Prdm1<tm2Masu>
  http://metadb.riken.jp/0000702I129P2OlaHsd129X1SvJGtROSA26Sortm1EYFPCosGtROSA26SorIghg1tm1creCgnIghg1Prdm1tm2MasuPrdm1tm2MasuIghg1tm1creCgnGtROSA26Sortm1EYFPCosIghg1GtROSA26SorPrdm1tm2Masu
• abnormal germinal center B cell physiology_Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>,Prdm1<tm2Masu>/Prdm1<tm2Masu>
  http://metadb.riken.jp/0008192I129P2OlaHsdC57BL6GtROSA26Sortm4IkbkbRskyGtROSA26SorIghg1tm1creCgnIghg1Prdm1tm2MasuPrdm1tm2MasuPrdm1tm2MasuGtROSA26Sortm4IkbkbRskyGtROSA26SorIghg1Ighg1tm1creCgn
• enlarged spleen_Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>/Gt(ROSA)26Sor<+>,Ighg1<tm1(cre)Cgn>/Ighg1<+>
  http://metadb.riken.jp/0000691I129P2OlaHsdC57BL6GtROSA26Sortm4IkbkbRskyGtROSA26SorIghg1tm1creCgnIghg1Ighg1tm1creCgnIghg1GtROSA26Sortm4IkbkbRskyGtROSA26Sor

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD17941
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD17941
• CD00215
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD00215