decreased mature B cell number_Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>,Igh-J<tm1Cgn>/Igh<tm4Cgn>,Tg(Cr2-cre)3Cgn/0

http://metadb.riken.jp/0008211I129P2OlaHsdC57BL6GtROSA26Sortm8Map2k1EGFPRskyGtROSA26Sortm8Map2k1EGFPRskyIghJtm1CgnIghtm4CgnTgCr2cre3Cgn0IghJtm1CgnIghtm4CgnTgCr2cre3CgnGtROSA26Sortm8Map2k1EGFPRsky

decreased mature B cell number_Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>,Igh-J<tm1Cgn>/Igh<tm4Cgn>,Tg(Cr2-cre)3Cgn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• immunoglobulin heavy chain, joining region
  http://metadb.riken.jp/db/mgi_rdf/MGI:96461
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion 3, University of Cologne
  http://metadb.riken.jp/db/mgi_rdf/MGI:3708319
• immunoglobulin heavy chain complex
  http://metadb.riken.jp/db/mgi_rdf/MGI:96442

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>,Igh-J<tm1Cgn>/Igh<tm4Cgn>,Tg(Cr2-cre)3Cgn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Igh-J<tm1Cgn>|Igh<tm4Cgn>|Tg(Cr2-cre)3Cgn|Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased mature B cell number
  http://purl.obolibrary.org/obo/MP_0008211

文献

http://purl.org/net/cito/citesAsAuthority

• Lakshmi. Srinivasan, et.al., PI3 kinase signals BCR-dependent mature B cell survival., Cell, 2009, 139
  http://rdf.ncbi.nlm.nih.gov/pubmed/19879843