decreased mature B cell number_Btk<tm1Wk>/Btk<tm1Wk>

http://metadb.riken.jp/0008211I129S4SvJaeC57BL6Btktm1WkBtktm1WkBtktm1Wk

decreased mature B cell number_Btk<tm1Wk>/Btk<tm1Wk>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Bruton agammaglobulinemia tyrosine kinase
  http://metadb.riken.jp/db/mgi_rdf/MGI:88216

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Btk<tm1Wk>/Btk<tm1Wk>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Btk<tm1Wk>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased mature B cell number
  http://purl.obolibrary.org/obo/MP_0008211

文献

http://purl.org/net/cito/citesAsAuthority

• W N. Khan, et.al., Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40., International immunology, 1997, 9
  http://rdf.ncbi.nlm.nih.gov/pubmed/9088978
• W N. Khan, et.al., Defective B cell development and function in Btk-deficient mice., Immunity, 1995, 3
  http://rdf.ncbi.nlm.nih.gov/pubmed/7552994