W N. Khan, et.al., Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40., International immunology, 1997, 9

http://rdf.ncbi.nlm.nih.gov/pubmed/9088978

W N. Khan, et.al., Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40., International immunology, 1997, 9

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• absent spleen germinal center_Btk<tm1Wk>/Btk<tm1Wk>,Cd40<tm1Geha>/Cd40<tm1Geha>
  http://metadb.riken.jp/0008474I129S4SvJaeC57BL6Btktm1WkBtktm1WkCd40tm1GehaCd40tm1GehaCd40tm1GehaBtktm1Wk
• decreased B cell number_Btk<tm1Wk>/Btk<tm1Wk>,Cd40<tm1Geha>/Cd40<tm1Geha>
  http://metadb.riken.jp/0005017I129S4SvJaeC57BL6Btktm1WkBtktm1WkCd40tm1GehaCd40tm1GehaCd40tm1GehaBtktm1Wk
• decreased IgG3 level_Btk<tm1Wk>/Btk<tm1Wk>
  http://metadb.riken.jp/0008498I129S4SvJaeC57BL6Btktm1WkBtktm1WkBtktm1Wk
• decreased spleen germinal center size_Cd40<tm1Geha>/Cd40<tm1Geha>
  http://metadb.riken.jp/0008484I129S4SvJaeC57BL6Cd40tm1GehaCd40tm1GehaCd40tm1Geha
• decreased IgM level_Btk<tm1Wk>/Btk<tm1Wk>,Cd40<tm1Geha>/Cd40<tm1Geha>
  http://metadb.riken.jp/0001806I129S4SvJaeC57BL6Btktm1WkBtktm1WkCd40tm1GehaCd40tm1GehaCd40tm1GehaBtktm1Wk
• decreased IgA level_Btk<tm1Wk>/Btk<tm1Wk>,Cd40<tm1Geha>/Cd40<tm1Geha>
  http://metadb.riken.jp/0001807I129S4SvJaeC57BL6Btktm1WkBtktm1WkCd40tm1GehaCd40tm1GehaCd40tm1GehaBtktm1Wk
• decreased IgM level_Btk<tm1Wk>/Btk<tm1Wk>
  http://metadb.riken.jp/0001806I129S4SvJaeC57BL6Btktm1WkBtktm1WkBtktm1Wk
• decreased spleen germinal center size_Btk<tm1Wk>/Btk<tm1Wk>
  http://metadb.riken.jp/0008484I129S4SvJaeC57BL6Btktm1WkBtktm1WkBtktm1Wk
• decreased IgG2a level_Btk<tm1Wk>/Btk<tm1Wk>,Cd40<tm1Geha>/Cd40<tm1Geha>
  http://metadb.riken.jp/0008496I129S4SvJaeC57BL6Btktm1WkBtktm1WkCd40tm1GehaCd40tm1GehaCd40tm1GehaBtktm1Wk
• decreased IgG3 level_Btk<tm1Wk>/Btk<tm1Wk>,Cd40<tm1Geha>/Cd40<tm1Geha>
  http://metadb.riken.jp/0008498I129S4SvJaeC57BL6Btktm1WkBtktm1WkCd40tm1GehaCd40tm1GehaCd40tm1GehaBtktm1Wk
• decreased IgG2b level_Cd40<tm1Geha>/Cd40<tm1Geha>
  http://metadb.riken.jp/0008497I129S4SvJaeC57BL6Cd40tm1GehaCd40tm1GehaCd40tm1Geha
• decreased IgG1 level_Cd40<tm1Geha>/Cd40<tm1Geha>
  http://metadb.riken.jp/0008495I129S4SvJaeC57BL6Cd40tm1GehaCd40tm1GehaCd40tm1Geha
• abnormal lymph node germinal center morphology_Cd40<tm1Geha>/Cd40<tm1Geha>
  http://metadb.riken.jp/0008522I129S4SvJaeC57BL6Cd40tm1GehaCd40tm1GehaCd40tm1Geha
• absent lymph node germinal center_Btk<tm1Wk>/Btk<tm1Wk>,Cd40<tm1Geha>/Cd40<tm1Geha>
  http://metadb.riken.jp/0008523I129S4SvJaeC57BL6Btktm1WkBtktm1WkCd40tm1GehaCd40tm1GehaCd40tm1GehaBtktm1Wk
• decreased B cell proliferation_Btk<tm1Wk>/Btk<tm1Wk>,Cd40<tm1Geha>/Cd40<tm1Geha>
  http://metadb.riken.jp/0005093I129S4SvJaeC57BL6Btktm1WkBtktm1WkCd40tm1GehaCd40tm1GehaCd40tm1GehaBtktm1Wk
• abnormal lymph node germinal center morphology_Btk<tm1Wk>/Btk<tm1Wk>
  http://metadb.riken.jp/0008522I129S4SvJaeC57BL6Btktm1WkBtktm1WkBtktm1Wk
• decreased IgG2a level_Cd40<tm1Geha>/Cd40<tm1Geha>
  http://metadb.riken.jp/0008496I129S4SvJaeC57BL6Cd40tm1GehaCd40tm1GehaCd40tm1Geha
• decreased mature B cell number_Btk<tm1Wk>/Btk<tm1Wk>
  http://metadb.riken.jp/0008211I129S4SvJaeC57BL6Btktm1WkBtktm1WkBtktm1Wk
• decreased mature B cell number_Btk<tm1Wk>/Btk<tm1Wk>,Cd40<tm1Geha>/Cd40<tm1Geha>
  http://metadb.riken.jp/0008211I129S4SvJaeC57BL6Btktm1WkBtktm1WkCd40tm1GehaCd40tm1GehaCd40tm1GehaBtktm1Wk
• decreased spleen germinal center number_Btk<tm1Wk>/Btk<tm1Wk>
  http://metadb.riken.jp/0008482I129S4SvJaeC57BL6Btktm1WkBtktm1WkBtktm1Wk
• decreased spleen germinal center number_Cd40<tm1Geha>/Cd40<tm1Geha>
  http://metadb.riken.jp/0008482I129S4SvJaeC57BL6Cd40tm1GehaCd40tm1GehaCd40tm1Geha
• decreased IgA level_Cd40<tm1Geha>/Cd40<tm1Geha>
  http://metadb.riken.jp/0001807I129S4SvJaeC57BL6Cd40tm1GehaCd40tm1GehaCd40tm1Geha
• decreased IgG2b level_Btk<tm1Wk>/Btk<tm1Wk>,Cd40<tm1Geha>/Cd40<tm1Geha>
  http://metadb.riken.jp/0008497I129S4SvJaeC57BL6Btktm1WkBtktm1WkCd40tm1GehaCd40tm1GehaCd40tm1GehaBtktm1Wk
• decreased B cell proliferation_Btk<tm1Wk>/Btk<tm1Wk>
  http://metadb.riken.jp/0005093I129S4SvJaeC57BL6Btktm1WkBtktm1WkBtktm1Wk
• abnormal humoral immune response_Btk<tm1Wk>/Btk<tm1Wk>,Cd40<tm1Geha>/Cd40<tm1Geha>
  http://metadb.riken.jp/0001800I129S4SvJaeC57BL6Btktm1WkBtktm1WkCd40tm1GehaCd40tm1GehaCd40tm1GehaBtktm1Wk