decreased somatotroph cell number_Lepr<tm1.1Chua>/Lepr<+>,Tg(Gh1-cre)bKnmn/0

http://metadb.riken.jp/0008329I129C57BL6FVBLeprtm11ChuaLeprTgGh1crebKnmn0Leprtm11ChuaTgGh1crebKnmnLepr

decreased somatotroph cell number_Lepr<tm1.1Chua>/Lepr<+>,Tg(Gh1-cre)bKnmn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• leptin receptor
  http://metadb.riken.jp/db/mgi_rdf/MGI:104993
• transgene insertion b, Rhonda D Kineman
  http://metadb.riken.jp/db/mgi_rdf/MGI:4442900

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Lepr<tm1.1Chua>/Lepr<+>,Tg(Gh1-cre)bKnmn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Lepr<tm1.1Chua>|Tg(Gh1-cre)bKnmn|Lepr<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6 * FVB

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased somatotroph cell number
  http://purl.obolibrary.org/obo/MP_0008329

文献

http://purl.org/net/cito/citesAsAuthority

• Gwen V. Childs, et.al., The somatotrope as a metabolic sensor: deletion of leptin receptors causes obesity., Endocrinology, 2011, 152
  http://rdf.ncbi.nlm.nih.gov/pubmed/21084451