decreased corticotroph cell number_Gt(ROSA)26Sor<tm1(CAG-Foxo1*)Jcbr>/Gt(ROSA)26Sor<+>,Pdpk1<tm1Jcbr>/Pdpk1<tm1Jcbr>,Tg(Pomc1-cre)16Lowl/0

http://metadb.riken.jp/0008341IC57BL6FVBNGtROSA26Sortm1CAGFoxo1JcbrGtROSA26SorPdpk1tm1JcbrPdpk1tm1JcbrTgPomc1cre16Lowl0Pdpk1tm1JcbrGtROSA26SorTgPomc1cre16LowlGtROSA26Sortm1CAGFoxo1Jcbr

decreased corticotroph cell number_Gt(ROSA)26Sor<tm1(CAG-Foxo1*)Jcbr>/Gt(ROSA)26Sor<+>,Pdpk1<tm1Jcbr>/Pdpk1<tm1Jcbr>,Tg(Pomc1-cre)16Lowl/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• 3-phosphoinositide dependent protein kinase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1338068
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion 16, Bradford B Lowell
  http://metadb.riken.jp/db/mgi_rdf/MGI:3640615

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(CAG-Foxo1*)Jcbr>/Gt(ROSA)26Sor<+>,Pdpk1<tm1Jcbr>/Pdpk1<tm1Jcbr>,Tg(Pomc1-cre)16Lowl/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pdpk1<tm1Jcbr>|Gt(ROSA)26Sor<+>|Tg(Pomc1-cre)16Lowl|Gt(ROSA)26Sor<tm1(CAG-Foxo1*)Jcbr>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased corticotroph cell number
  http://purl.obolibrary.org/obo/MP_0008341

文献

http://purl.org/net/cito/citesAsAuthority

• Bengt F. Belgardt, et.al., PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response., Cell metabolism, 2008, 7
  http://rdf.ncbi.nlm.nih.gov/pubmed/18396135