Bengt F. Belgardt, et.al., PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response., Cell metabolism, 2008, 7

http://rdf.ncbi.nlm.nih.gov/pubmed/18396135

Bengt F. Belgardt, et.al., PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response., Cell metabolism, 2008, 7

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1(CAG-Foxo1*)Jcbr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3790725
• Pdpk1<tm1Jcbr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3790718

class

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1(CAG-Foxo1*)Jcbr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3790725
• Pdpk1<tm1Jcbr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3790718

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased circulating glucose level_Pdpk1<tm1Jcbr>/Pdpk1<tm1Jcbr>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0005560IC57BL6FVBNPdpk1tm1JcbrPdpk1tm1JcbrTgPomc1cre16Lowl0Pdpk1tm1JcbrTgPomc1cre16Lowl
• decreased insulin secretion_Pdpk1<tm1Jcbr>/Pdpk1<tm1Jcbr>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0003059IC57BL6FVBNPdpk1tm1JcbrPdpk1tm1JcbrTgPomc1cre16Lowl0Pdpk1tm1JcbrTgPomc1cre16Lowl
• abnormal glucose homeostasis_Pdpk1<tm1Jcbr>/Pdpk1<tm1Jcbr>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0002078IC57BL6FVBNPdpk1tm1JcbrPdpk1tm1JcbrTgPomc1cre16Lowl0Pdpk1tm1JcbrTgPomc1cre16Lowl
• increased insulin sensitivity_Pdpk1<tm1Jcbr>/Pdpk1<tm1Jcbr>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0002891IC57BL6FVBNPdpk1tm1JcbrPdpk1tm1JcbrTgPomc1cre16Lowl0Pdpk1tm1JcbrTgPomc1cre16Lowl
• decreased circulating corticosterone level_Pdpk1<tm1Jcbr>/Pdpk1<tm1Jcbr>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0002665IC57BL6FVBNPdpk1tm1JcbrPdpk1tm1JcbrTgPomc1cre16Lowl0Pdpk1tm1JcbrTgPomc1cre16Lowl
• decreased corticotroph cell number_Gt(ROSA)26Sor<tm1(CAG-Foxo1*)Jcbr>/Gt(ROSA)26Sor<+>,Pdpk1<tm1Jcbr>/Pdpk1<tm1Jcbr>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0008341IC57BL6FVBNGtROSA26Sortm1CAGFoxo1JcbrGtROSA26SorPdpk1tm1JcbrPdpk1tm1JcbrTgPomc1cre16Lowl0Pdpk1tm1JcbrGtROSA26SorTgPomc1cre16LowlGtROSA26Sortm1CAGFoxo1Jcbr
• improved glucose tolerance_Pdpk1<tm1Jcbr>/Pdpk1<tm1Jcbr>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0005292IC57BL6FVBNPdpk1tm1JcbrPdpk1tm1JcbrTgPomc1cre16Lowl0Pdpk1tm1JcbrTgPomc1cre16Lowl
• decreased circulating corticosterone level_Gt(ROSA)26Sor<tm1(CAG-Foxo1*)Jcbr>/Gt(ROSA)26Sor<+>,Pdpk1<tm1Jcbr>/Pdpk1<tm1Jcbr>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0002665IC57BL6FVBNGtROSA26Sortm1CAGFoxo1JcbrGtROSA26SorPdpk1tm1JcbrPdpk1tm1JcbrTgPomc1cre16Lowl0Pdpk1tm1JcbrGtROSA26SorTgPomc1cre16LowlGtROSA26Sortm1CAGFoxo1Jcbr
• abnormal melanotroph morphology_Pdpk1<tm1Jcbr>/Pdpk1<tm1Jcbr>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0008324IC57BL6FVBNPdpk1tm1JcbrPdpk1tm1JcbrTgPomc1cre16Lowl0Pdpk1tm1JcbrTgPomc1cre16Lowl
• increased circulating glucose level_Pdpk1<tm1Jcbr>/Pdpk1<tm1Jcbr>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0005559IC57BL6FVBNPdpk1tm1JcbrPdpk1tm1JcbrTgPomc1cre16Lowl0Pdpk1tm1JcbrTgPomc1cre16Lowl
• decreased corticotroph cell number_Pdpk1<tm1Jcbr>/Pdpk1<tm1Jcbr>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0008341IC57BL6FVBNPdpk1tm1JcbrPdpk1tm1JcbrTgPomc1cre16Lowl0Pdpk1tm1JcbrTgPomc1cre16Lowl
• abnormal circulating leptin level_Pdpk1<tm1Jcbr>/Pdpk1<tm1Jcbr>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0005667IC57BL6FVBNPdpk1tm1JcbrPdpk1tm1JcbrTgPomc1cre16Lowl0Pdpk1tm1JcbrTgPomc1cre16Lowl
• increased body weight_Pdpk1<tm1Jcbr>/Pdpk1<tm1Jcbr>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0001260IC57BL6FVBNPdpk1tm1JcbrPdpk1tm1JcbrTgPomc1cre16Lowl0Pdpk1tm1JcbrTgPomc1cre16Lowl
• polyphagia_Pdpk1<tm1Jcbr>/Pdpk1<tm1Jcbr>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0001433IC57BL6FVBNPdpk1tm1JcbrPdpk1tm1JcbrTgPomc1cre16Lowl0Pdpk1tm1JcbrTgPomc1cre16Lowl
• decreased gonadal fat pad weight_Pdpk1<tm1Jcbr>/Pdpk1<tm1Jcbr>,Tg(Pomc1-cre)16Lowl/0
  http://metadb.riken.jp/0009283IC57BL6FVBNPdpk1tm1JcbrPdpk1tm1JcbrTgPomc1cre16Lowl0Pdpk1tm1JcbrTgPomc1cre16Lowl