increased IgG1 level_Lat<tm4Mal>/Lat<tm4Mal>,Tg(Lck*F505)3073Rmp/?

http://metadb.riken.jp/0008499I129P2OlaHsdC57BL6DBA2Lattm4MalLattm4MalTgLckF5053073RmpTgLckF5053073RmpLattm4Mal

increased IgG1 level_Lat<tm4Mal>/Lat<tm4Mal>,Tg(Lck*F505)3073Rmp/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 3073, Roger M Perlmutter
  http://metadb.riken.jp/db/mgi_rdf/MGI:3032765
• linker for activation of T cells
  http://metadb.riken.jp/db/mgi_rdf/MGI:1342293

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Lat<tm4Mal>/Lat<tm4Mal>,Tg(Lck*F505)3073Rmp/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Lck*F505)3073Rmp|Lat<tm4Mal>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased IgG1 level
  http://purl.obolibrary.org/obo/MP_0008499

文献

http://purl.org/net/cito/citesAsAuthority

• Michael. Mingueneau, et.al., Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor., Immunity, 2009, 31
  http://rdf.ncbi.nlm.nih.gov/pubmed/19682930