Michael. Mingueneau, et.al., Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor., Immunity, 2009, 31

http://rdf.ncbi.nlm.nih.gov/pubmed/19682930

Michael. Mingueneau, et.al., Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor., Immunity, 2009, 31

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased interferon-gamma secretion_Lat<tm6(DTR)Mal>/Lat<tm6(DTR)Mal>
  http://metadb.riken.jp/0008567I129S2SvPasC57BL6Lattm6DTRMalLattm6DTRMalLattm6DTRMal
• increased interleukin-4 secretion_Lat<tm4Mal>/Lat<tm4Mal>,Tg(Lck*F505)3073Rmp/?
  http://metadb.riken.jp/0008699I129P2OlaHsdC57BL6DBA2Lattm4MalLattm4MalTgLckF5053073RmpTgLckF5053073RmpLattm4Mal
• abnormal T-helper 2 physiology_Il4<tm1Lky>/Il4<+>,Lat<tm1Mal>/Lat<tm1Mal>
  http://metadb.riken.jp/0005466I129S2SvPasC57BL6Il4tm1LkyIl4Lattm1MalLattm1MalIl4Il4tm1LkyLattm1Mal
• abnormal T-helper 2 physiology_Lat<tm1Mal>/Lat<tm6(DTR)Mal>
  http://metadb.riken.jp/0005466I129S2SvPasC57BL6Lattm1MalLattm6DTRMalLattm1MalLattm6DTRMal
• increased IgG1 level_Lat<tm4Mal>/Lat<tm4Mal>,Tg(Lck*F505)3073Rmp/?
  http://metadb.riken.jp/0008499I129P2OlaHsdC57BL6DBA2Lattm4MalLattm4MalTgLckF5053073RmpTgLckF5053073RmpLattm4Mal
• abnormal T cell activation_Lat<tm6(DTR)Mal>/Lat<tm6(DTR)Mal>
  http://metadb.riken.jp/0001828I129S2SvPasC57BL6Lattm6DTRMalLattm6DTRMalLattm6DTRMal
• spleen hyperplasia_Lat<tm4Mal>/Lat<tm4Mal>,Tg(Lck*F505)3073Rmp/?
  http://metadb.riken.jp/0000693I129P2OlaHsdC57BL6DBA2Lattm4MalLattm4MalTgLckF5053073RmpTgLckF5053073RmpLattm4Mal
• abnormal T-helper 2 physiology_Lat<tm6(DTR)Mal>/Lat<tm6(DTR)Mal>
  http://metadb.riken.jp/0005466I129S2SvPasC57BL6Lattm6DTRMalLattm6DTRMalLattm6DTRMal
• increased CD4-positive, alpha beta T cell number_Lat<tm4Mal>/Lat<tm4Mal>,Tg(Lck*F505)3073Rmp/?
  http://metadb.riken.jp/0008074I129P2OlaHsdC57BL6DBA2Lattm4MalLattm4MalTgLckF5053073RmpTgLckF5053073RmpLattm4Mal
• abnormal T-helper 2 physiology_Lat<tm4Mal>/Lat<tm4Mal>,Tg(Lck*F505)3073Rmp/?
  http://metadb.riken.jp/0005466I129P2OlaHsdC57BL6DBA2Lattm4MalLattm4MalTgLckF5053073RmpTgLckF5053073RmpLattm4Mal
• abnormal T-helper 2 physiology_Lat<tm4Mal>/Lat<tm6(DTR)Mal>
  http://metadb.riken.jp/0005466I129P2OlaHsd129S2SvPasC57BL6Lattm4MalLattm6DTRMalLattm6DTRMalLattm4Mal
• increased IgE level_Lat<tm4Mal>/Lat<tm4Mal>,Tg(Lck*F505)3073Rmp/?
  http://metadb.riken.jp/0002497I129P2OlaHsdC57BL6DBA2Lattm4MalLattm4MalTgLckF5053073RmpTgLckF5053073RmpLattm4Mal