increased circulating interleukin-17 level_Adam17<tm1.2Bbl>/Adam17<tm1.2Bbl>,Sox9<tm3(cre)Crm>/Sox9<+>

http://metadb.riken.jp/0008614I129P2OlaHsd129S7SvEvBrdC57BL6Adam17tm12BblAdam17tm12BblSox9tm3creCrmSox9Sox9Sox9tm3creCrmAdam17tm12Bbl

increased circulating interleukin-17 level_Adam17<tm1.2Bbl>/Adam17<tm1.2Bbl>,Sox9<tm3(cre)Crm>/Sox9<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• a disintegrin and metallopeptidase domain 17
  http://metadb.riken.jp/db/mgi_rdf/MGI:1096335
• SRY (sex determining region Y)-box 9
  http://metadb.riken.jp/db/mgi_rdf/MGI:98371

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Adam17<tm1.2Bbl>/Adam17<tm1.2Bbl>,Sox9<tm3(cre)Crm>/Sox9<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Sox9<+>|Sox9<tm3(cre)Crm>|Adam17<tm1.2Bbl>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased circulating interleukin-17 level
  http://purl.obolibrary.org/obo/MP_0008614

文献

http://purl.org/net/cito/citesAsAuthority

• Keisuke. Horiuchi, et.al., Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF., Journal of immunology (Baltimore, Md. : 1950), 2009, 182
  http://rdf.ncbi.nlm.nih.gov/pubmed/19201862