increased circulating interleukin-18 level_Hmgb1<tm1.1Ttg>/Hmgb1<tm1.1Ttg>,Tg(Itgax-cre)1-1Reiz/0

http://metadb.riken.jp/0008635I129P2OlaHsdC57BL6CBAHmgb1tm11TtgHmgb1tm11TtgTgItgaxcre11Reiz0Hmgb1tm11TtgTgItgaxcre11Reiz

increased circulating interleukin-18 level_Hmgb1<tm1.1Ttg>/Hmgb1<tm1.1Ttg>,Tg(Itgax-cre)1-1Reiz/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• high mobility group box 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:96113
• transgene insertion 1-1, Boris Reizis
  http://metadb.riken.jp/db/mgi_rdf/MGI:3763247

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Hmgb1<tm1.1Ttg>/Hmgb1<tm1.1Ttg>,Tg(Itgax-cre)1-1Reiz/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Hmgb1<tm1.1Ttg>|Tg(Itgax-cre)1-1Reiz

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased circulating interleukin-18 level
  http://purl.obolibrary.org/obo/MP_0008635

文献

http://purl.org/net/cito/citesAsAuthority

• Hideyuki. Yanai, et.al., Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110
  http://rdf.ncbi.nlm.nih.gov/pubmed/24302768