Hideyuki. Yanai, et.al., Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110

http://rdf.ncbi.nlm.nih.gov/pubmed/24302768

Hideyuki. Yanai, et.al., Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Hmgb1<tm1.1Ttg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5563518
• Hmgb1<tm1.2Ttg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5563524

class

http://purl.org/net/cito/citesAsAuthority

• Hmgb1<tm1.1Ttg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5563518
• Hmgb1<tm1.2Ttg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5563524

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased macrophage cell number_Hmgb1<tm1.1Ttg>/Hmgb1<tm1.1Ttg>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0003884I129P2OlaHsdHmgb1tm11TtgHmgb1tm11TtgLyz2tm1creIfoLyz2Hmgb1tm11TtgLyz2Lyz2tm1creIfo
• increased macrophage apoptosis_Hmgb1<tm1.1Ttg>/Hmgb1<tm1.1Ttg>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0011080I129P2OlaHsdHmgb1tm11TtgHmgb1tm11TtgLyz2tm1creIfoLyz2Hmgb1tm11TtgLyz2Lyz2tm1creIfo
• increased interleukin-18 secretion_Hmgb1<tm1.1Ttg>/Hmgb1<tm1.1Ttg>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0008684I129P2OlaHsdHmgb1tm11TtgHmgb1tm11TtgLyz2tm1creIfoLyz2Hmgb1tm11TtgLyz2Lyz2tm1creIfo
• increased circulating interleukin-1 beta level_Hmgb1<tm1.1Ttg>/Hmgb1<tm1.1Ttg>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0008641I129P2OlaHsdC57BL6CBAHmgb1tm11TtgHmgb1tm11TtgTgItgaxcre11Reiz0Hmgb1tm11TtgTgItgaxcre11Reiz
• increased circulating interleukin-18 level_Hmgb1<tm1.1Ttg>/Hmgb1<tm1.1Ttg>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0008635I129P2OlaHsdC57BL6DBAHmgb1tm11TtgHmgb1tm11TtgTgAlbcre21Mgn0TgAlbcre21MgnHmgb1tm11Ttg
• neonatal lethality, complete penetrance_Hmgb1<tm1.1Ttg>/Hmgb1<tm1.2Ttg>,Tg(CAG-cre)13Miya/0
  http://metadb.riken.jp/0011087I129P2OlaHsdC57BL6Hmgb1tm11TtgHmgb1tm12TtgTgCAGcre13Miya0Hmgb1tm12TtgHmgb1tm11TtgTgCAGcre13Miya
• abnormal macrophage physiology_Hmgb1<tm1.1Ttg>/Hmgb1<tm1.1Ttg>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0002451I129P2OlaHsdHmgb1tm11TtgHmgb1tm11TtgLyz2tm1creIfoLyz2Hmgb1tm11TtgLyz2Lyz2tm1creIfo
• increased susceptibility to bacterial infection_Hmgb1<tm1.1Ttg>/Hmgb1<tm1.1Ttg>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0002412I129P2OlaHsdHmgb1tm11TtgHmgb1tm11TtgLyz2tm1creIfoLyz2Hmgb1tm11TtgLyz2Lyz2tm1creIfo
• increased circulating interleukin-1 beta level_Hmgb1<tm1.1Ttg>/Hmgb1<tm1.1Ttg>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0008641I129P2OlaHsdHmgb1tm11TtgHmgb1tm11TtgLyz2tm1creIfoLyz2Hmgb1tm11TtgLyz2Lyz2tm1creIfo
• impaired macrophage phagocytosis_Hmgb1<tm1.1Ttg>/Hmgb1<tm1.1Ttg>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0001798I129P2OlaHsdHmgb1tm11TtgHmgb1tm11TtgLyz2tm1creIfoLyz2Hmgb1tm11TtgLyz2Lyz2tm1creIfo
• increased sensitivity to induced cell death_Hmgb1<tm1.1Ttg>/Hmgb1<tm1.1Ttg>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0008943I129P2OlaHsdHmgb1tm11TtgHmgb1tm11TtgLyz2tm1creIfoLyz2Hmgb1tm11TtgLyz2Lyz2tm1creIfo
• increased interleukin-1 beta secretion_Hmgb1<tm1.1Ttg>/Hmgb1<tm1.1Ttg>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0008657I129P2OlaHsdHmgb1tm11TtgHmgb1tm11TtgLyz2tm1creIfoLyz2Hmgb1tm11TtgLyz2Lyz2tm1creIfo
• increased susceptibility to endotoxin shock_Hmgb1<tm1.1Ttg>/Hmgb1<tm1.1Ttg>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0008735I129P2OlaHsdHmgb1tm11TtgHmgb1tm11TtgLyz2tm1creIfoLyz2Hmgb1tm11TtgLyz2Lyz2tm1creIfo
• increased circulating interleukin-18 level_Hmgb1<tm1.1Ttg>/Hmgb1<tm1.1Ttg>,Lyz2<tm1(cre)Ifo>/Lyz2<+>
  http://metadb.riken.jp/0008635I129P2OlaHsdHmgb1tm11TtgHmgb1tm11TtgLyz2tm1creIfoLyz2Hmgb1tm11TtgLyz2Lyz2tm1creIfo
• increased circulating interleukin-1 beta level_Hmgb1<tm1.1Ttg>/Hmgb1<tm1.1Ttg>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0008641I129P2OlaHsdC57BL6DBAHmgb1tm11TtgHmgb1tm11TtgTgAlbcre21Mgn0TgAlbcre21MgnHmgb1tm11Ttg
• increased circulating interleukin-18 level_Hmgb1<tm1.1Ttg>/Hmgb1<tm1.1Ttg>,Tg(Itgax-cre)1-1Reiz/0
  http://metadb.riken.jp/0008635I129P2OlaHsdC57BL6CBAHmgb1tm11TtgHmgb1tm11TtgTgItgaxcre11Reiz0Hmgb1tm11TtgTgItgaxcre11Reiz

article

http://www.w3.org/2000/01/rdf-schema#seeAlso

• [Blank]

BRC マウスの系統

http://purl.org/net/cito/citesAsAuthority

• B6.129P2-Hmgb1<tm1Ttg>
  http://metadb.riken.jp/db/rikenbrc_mouse/RBRC06240

article

http://www.w3.org/2000/01/rdf-schema#seeAlso

• [Blank]