decreased interleukin-1 beta secretion_Casp1<tm1Sesh>/Casp1<tm1Sesh>,Casp4<del>/Casp4<del>,Tg(Casp4)#Gne/0

http://metadb.riken.jp/0008658I129S2SvPasC57BL6NODShiLtJCasp1tm1SeshCasp1tm1SeshCasp4delCasp4delTgCasp4Gne0TgCasp4GneCasp1tm1SeshCasp4del

decreased interleukin-1 beta secretion_Casp1<tm1Sesh>/Casp1<tm1Sesh>,Casp4<del>/Casp4<del>,Tg(Casp4)#Gne/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• caspase 4, apoptosis-related cysteine peptidase
  http://metadb.riken.jp/db/mgi_rdf/MGI:107700
• caspase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:96544
• transgene insertion, Genentech
  http://metadb.riken.jp/db/mgi_rdf/MGI:5468961

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Casp1<tm1Sesh>/Casp1<tm1Sesh>,Casp4<del>/Casp4<del>,Tg(Casp4)#Gne/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Casp4)#Gne|Casp1<tm1Sesh>|Casp4<del>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S2/SvPas * C57BL/6 * NOD/ShiLtJ

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased interleukin-1 beta secretion
  http://purl.obolibrary.org/obo/MP_0008658

文献

http://purl.org/net/cito/citesAsAuthority

• Nobuhiko. Kayagaki, et.al., Non-canonical inflammasome activation targets caspase-11., Nature, 2011, 479
  http://rdf.ncbi.nlm.nih.gov/pubmed/22002608