decreased interleukin-2 secretion_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0

http://metadb.riken.jp/0008688I129X1SvJC57BL6DBA2GtROSA26Sortm1EYFPCosGtROSA26SorPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0Plcg1tm1GcrpPlcg1tm1RwenGtROSA26SorTgCd4cre1CwiGtROSA26Sortm1EYFPCos

decreased interleukin-2 secretion_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1, Christopher B Wilson
  http://metadb.riken.jp/db/mgi_rdf/MGI:2448688
• phospholipase C, gamma 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97615
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Plcg1<tm1Gcrp>|Plcg1<tm1Rwen>|Gt(ROSA)26Sor<+>|Tg(Cd4-cre)1Cwi|Gt(ROSA)26Sor<tm1(EYFP)Cos>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129X1/SvJ * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased interleukin-2 secretion
  http://purl.obolibrary.org/obo/MP_0008688

文献

http://purl.org/net/cito/citesAsAuthority

• Guoping. Fu, et.al., Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance., The Journal of experimental medicine, 2010, 207
  http://rdf.ncbi.nlm.nih.gov/pubmed/20123962