decreased susceptibility to endotoxin shock_Adam17<tm1Bbl>/Adam17<tm1Bbl>,Tg(Mx1-cre)1Cgn/0

http://metadb.riken.jp/0008734I129P2OlaHsdC57BL6CBAAdam17tm1BblAdam17tm1BblTgMx1cre1Cgn0TgMx1cre1CgnAdam17tm1Bbl

decreased susceptibility to endotoxin shock_Adam17<tm1Bbl>/Adam17<tm1Bbl>,Tg(Mx1-cre)1Cgn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• a disintegrin and metallopeptidase domain 17
  http://metadb.riken.jp/db/mgi_rdf/MGI:1096335
• transgene insertion 1, University of Cologne
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176072

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Adam17<tm1Bbl>/Adam17<tm1Bbl>,Tg(Mx1-cre)1Cgn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Mx1-cre)1Cgn|Adam17<tm1Bbl>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased susceptibility to endotoxin shock
  http://purl.obolibrary.org/obo/MP_0008734

文献

http://purl.org/net/cito/citesAsAuthority

• Keisuke. Horiuchi, et.al., Cutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock., Journal of immunology (Baltimore, Md. : 1950), 2007, 179
  http://rdf.ncbi.nlm.nih.gov/pubmed/17709479