decreased survivor rate_Prkar1a<tm1.2Lsk>/Prkar1a<+>,Pten<tm1.1Mwst>/Pten<+>,Tg(TPO-cre)1Shk/0

http://metadb.riken.jp/0008770I129S1Sv129X1SvJFVBNCrPrkar1atm12LskPrkar1aPtentm11MwstPtenTgTPOcre1Shk0TgTPOcre1ShkPtenPrkar1atm12LskPtentm11MwstPrkar1a

decreased survivor rate_Prkar1a<tm1.2Lsk>/Prkar1a<+>,Pten<tm1.1Mwst>/Pten<+>,Tg(TPO-cre)1Shk/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583
• protein kinase, cAMP dependent regulatory, type I, alpha
  http://metadb.riken.jp/db/mgi_rdf/MGI:104878
• transgene insertion 1, Shioko Kimura
  http://metadb.riken.jp/db/mgi_rdf/MGI:3653643

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Prkar1a<tm1.2Lsk>/Prkar1a<+>,Pten<tm1.1Mwst>/Pten<+>,Tg(TPO-cre)1Shk/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(TPO-cre)1Shk|Pten<+>|Prkar1a<tm1.2Lsk>|Pten<tm1.1Mwst>|Prkar1a<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ * FVB/NCr

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased survivor rate
  http://purl.obolibrary.org/obo/MP_0008770

文献

http://purl.org/net/cito/citesAsAuthority

• Daphne R. Pringle, et.al., Follicular thyroid cancers demonstrate dual activation of PKA and mTOR as modeled by thyroid-specific deletion of Prkar1a and Pten in mice., The Journal of clinical endocrinology and metabolism, 2014, 99
  http://rdf.ncbi.nlm.nih.gov/pubmed/24512487