Daphne R. Pringle, et.al., Follicular thyroid cancers demonstrate dual activation of PKA and mTOR as modeled by thyroid-specific deletion of Prkar1a and Pten in mice., The Journal of clinical endocrinology and metabolism, 2014, 99

http://rdf.ncbi.nlm.nih.gov/pubmed/24512487

Daphne R. Pringle, et.al., Follicular thyroid cancers demonstrate dual activation of PKA and mTOR as modeled by thyroid-specific deletion of Prkar1a and Pten in mice., The Journal of clinical endocrinology and metabolism, 2014, 99

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• weight loss_Prkar1a<tm1.2Lsk>/Prkar1a<tm1.2Lsk>,Pten<tm1.1Mwst>/Pten<tm1.1Mwst>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0001263I129S1Sv129X1SvJFVBNCrPrkar1atm12LskPrkar1atm12LskPtentm11MwstPtentm11MwstTgTPOcre1Shk0Prkar1atm12LskPtentm11MwstTgTPOcre1Shk
• increased metastatic potential_Prkar1a<tm1.2Lsk>/Prkar1a<tm1.2Lsk>,Pten<tm1.1Mwst>/Pten<tm1.1Mwst>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0001272I129S1Sv129X1SvJFVBNCrPrkar1atm12LskPrkar1atm12LskPtentm11MwstPtentm11MwstTgTPOcre1Shk0Prkar1atm12LskPtentm11MwstTgTPOcre1Shk
• premature death_Prkar1a<tm1.2Lsk>/Prkar1a<tm1.2Lsk>,Pten<tm1.1Mwst>/Pten<tm1.1Mwst>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0002083I129S1Sv129X1SvJFVBNCrPrkar1atm12LskPrkar1atm12LskPtentm11MwstPtentm11MwstTgTPOcre1Shk0Prkar1atm12LskPtentm11MwstTgTPOcre1Shk
• increased activity of thyroid_Prkar1a<tm1.2Lsk>/Prkar1a<tm1.2Lsk>,Pten<tm1.1Mwst>/Pten<tm1.1Mwst>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0003502I129S1Sv129X1SvJFVBNCrPrkar1atm12LskPrkar1atm12LskPtentm11MwstPtentm11MwstTgTPOcre1Shk0Prkar1atm12LskPtentm11MwstTgTPOcre1Shk
• abnormal thyroid follicular cell morphology_Pten<tm1.1Mwst>/Pten<tm1.1Mwst>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0004697I129FVBNCrPtentm11MwstPtentm11MwstTgTPOcre1Shk0TgTPOcre1ShkPtentm11Mwst
• enlarged thyroid gland_Prkar1a<tm1.2Lsk>/Prkar1a<tm1.2Lsk>,Pten<tm1.1Mwst>/Pten<tm1.1Mwst>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0005355I129S1Sv129X1SvJFVBNCrPrkar1atm12LskPrkar1atm12LskPtentm11MwstPtentm11MwstTgTPOcre1Shk0Prkar1atm12LskPtentm11MwstTgTPOcre1Shk
他6件を見る
• increased circulating thyroxine level_Prkar1a<tm1.2Lsk>/Prkar1a<tm1.2Lsk>,Pten<tm1.1Mwst>/Pten<tm1.1Mwst>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0005477I129S1Sv129X1SvJFVBNCrPrkar1atm12LskPrkar1atm12LskPtentm11MwstPtentm11MwstTgTPOcre1Shk0Prkar1atm12LskPtentm11MwstTgTPOcre1Shk
• decreased survivor rate_Prkar1a<tm1.2Lsk>/Prkar1a<+>,Pten<tm1.1Mwst>/Pten<+>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0008770I129S1Sv129X1SvJFVBNCrPrkar1atm12LskPrkar1aPtentm11MwstPtenTgTPOcre1Shk0TgTPOcre1ShkPtenPrkar1atm12LskPtentm11MwstPrkar1a
• decreased subcutaneous adipose tissue amount_Prkar1a<tm1.2Lsk>/Prkar1a<tm1.2Lsk>,Pten<tm1.1Mwst>/Pten<tm1.1Mwst>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0008844I129S1Sv129X1SvJFVBNCrPrkar1atm12LskPrkar1atm12LskPtentm11MwstPtentm11MwstTgTPOcre1Shk0Prkar1atm12LskPtentm11MwstTgTPOcre1Shk
• decreased abdominal adipose tissue amount_Prkar1a<tm1.2Lsk>/Prkar1a<tm1.2Lsk>,Pten<tm1.1Mwst>/Pten<tm1.1Mwst>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0008853I129S1Sv129X1SvJFVBNCrPrkar1atm12LskPrkar1atm12LskPtentm11MwstPtentm11MwstTgTPOcre1Shk0Prkar1atm12LskPtentm11MwstTgTPOcre1Shk
• increased thyroid carcinoma incidence_Prkar1a<tm1.2Lsk>/Prkar1a<tm1.2Lsk>,Pten<tm1.1Mwst>/Pten<tm1.1Mwst>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0010346I129S1Sv129X1SvJFVBNCrPrkar1atm12LskPrkar1atm12LskPtentm11MwstPtentm11MwstTgTPOcre1Shk0Prkar1atm12LskPtentm11MwstTgTPOcre1Shk
• increased thyroid carcinoma incidence_Prkar1a<tm1.2Lsk>/Prkar1a<tm1.2Lsk>,Tg(TPO-cre)1Shk/0
  http://metadb.riken.jp/0010346I129S1Sv129X1SvJFVBNCrPrkar1atm12LskPrkar1atm12LskTgTPOcre1Shk0Prkar1atm12LskTgTPOcre1Shk