increased physiological sensitivity to xenobiotic_Cyp1a1<tm1.1Dwn>/Cyp1a1<tm1.1Dwn>

http://metadb.riken.jp/0008873B6129P2Cyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11Dwn

increased physiological sensitivity to xenobiotic_Cyp1a1<tm1.1Dwn>/Cyp1a1<tm1.1Dwn>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• cytochrome P450, family 1, subfamily a, polypeptide 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88588

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cyp1a1<tm1.1Dwn>/Cyp1a1<tm1.1Dwn>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cyp1a1<tm1.1Dwn>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• B6.129P2-Cyp1a1<tm1.1Dwn>

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased physiological sensitivity to xenobiotic
  http://purl.obolibrary.org/obo/MP_0008873

文献

http://purl.org/net/cito/citesAsAuthority

• Manabu. Nukaya, et.al., The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology., Proceedings of the National Academy of Sciences of the United States of America, 2009, 106
  http://rdf.ncbi.nlm.nih.gov/pubmed/19261855
• Hongbin. Dong, et.al., Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: differing responses to dietary benzo[a]pyrene as proof of principle., Molecular pharmacology, 2009, 75
  http://rdf.ncbi.nlm.nih.gov/pubmed/19047483