Hongbin. Dong, et.al., Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: differing responses to dietary benzo[a]pyrene as proof of principle., Molecular pharmacology, 2009, 75

http://rdf.ncbi.nlm.nih.gov/pubmed/19047483

Hongbin. Dong, et.al., Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: differing responses to dietary benzo[a]pyrene as proof of principle., Molecular pharmacology, 2009, 75

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Cyp1a1<tm3.1Dwn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4830523
• Cyp1a1<tm4.1Dwn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4830524
• Cyp1a1<tm2.1Dwn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4830522

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased neutrophil cell number_Cyp1a1<tm1.1Dwn>/Cyp1a1<tm1.1Dwn>
  http://metadb.riken.jp/0000219B6129P2Cyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11Dwn
• increased physiological sensitivity to xenobiotic_Cyp1a1<tm3.1Dwn>/Cyp1a1<tm3.1Dwn>
  http://metadb.riken.jp/0008873B6129X1Cyp1a1tm31DwnCyp1a1tm31DwnCyp1a1tm31DwnCyp1a1tm31Dwn
• abnormal xenobiotic pharmacokinetics_Cyp1a1<tm1.1Dwn>/Cyp1a1<tm1.1Dwn>
  http://metadb.riken.jp/0008875B6129P2Cyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11Dwn
• decreased thymus weight_Cyp1a1<tm4.1Dwn>/Cyp1a1<tm4.1Dwn>
  http://metadb.riken.jp/0004956B6129X1Cyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41Dwn
• abnormal hemoglobin content_Cyp1a1<tm4.1Dwn>/Cyp1a1<tm4.1Dwn>
  http://metadb.riken.jp/0005563B6129X1Cyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41Dwn
• decreased lymphocyte cell number_Cyp1a1<tm1.1Dwn>/Cyp1a1<tm1.1Dwn>
  http://metadb.riken.jp/0005016B6129P2Cyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11Dwn
• decreased spleen weight_Cyp1a1<tm4.1Dwn>/Cyp1a1<tm4.1Dwn>
  http://metadb.riken.jp/0004953B6129X1Cyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41Dwn
• decreased spleen weight_Cyp1a1<tm1.1Dwn>/Cyp1a1<tm1.1Dwn>
  http://metadb.riken.jp/0004953B6129P2Cyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11Dwn
• decreased hematocrit_Cyp1a1<tm1.1Dwn>/Cyp1a1<tm1.1Dwn>
  http://metadb.riken.jp/0000208B6129P2Cyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11Dwn
• increased physiological sensitivity to xenobiotic_Cyp1a1<tm4.1Dwn>/Cyp1a1<tm4.1Dwn>
  http://metadb.riken.jp/0008873B6129X1Cyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41Dwn
• increased physiological sensitivity to xenobiotic_Cyp1a1<tm1.1Dwn>/Cyp1a1<tm1.1Dwn>
  http://metadb.riken.jp/0008873B6129P2Cyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11Dwn
• increased neutrophil cell number_Cyp1a1<tm4.1Dwn>/Cyp1a1<tm4.1Dwn>
  http://metadb.riken.jp/0000219B6129X1Cyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41Dwn
• increased liver weight_Cyp1a1<tm1.1Dwn>/Cyp1a1<tm1.1Dwn>
  http://metadb.riken.jp/0002981B6129P2Cyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11Dwn
• abnormal xenobiotic pharmacokinetics_Cyp1a1<tm4.1Dwn>/Cyp1a1<tm4.1Dwn>
  http://metadb.riken.jp/0008875B6129X1Cyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41Dwn
• increased circulating aspartate transaminase level_Cyp1a1<tm1.1Dwn>/Cyp1a1<tm1.1Dwn>
  http://metadb.riken.jp/0005343B6129P2Cyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11Dwn
• increased susceptibility to weight loss_Cyp1a1<tm4.1Dwn>/Cyp1a1<tm4.1Dwn>
  http://metadb.riken.jp/0010180B6129X1Cyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41Dwn
• increased hemoglobin content_Cyp1a1<tm1.1Dwn>/Cyp1a1<tm1.1Dwn>
  http://metadb.riken.jp/0005564B6129P2Cyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11Dwn
• increased circulating alanine transaminase level_Cyp1a1<tm1.1Dwn>/Cyp1a1<tm1.1Dwn>
  http://metadb.riken.jp/0002941B6129P2Cyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11Dwn
• increased liver weight_Cyp1a1<tm4.1Dwn>/Cyp1a1<tm4.1Dwn>
  http://metadb.riken.jp/0002981B6129X1Cyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41Dwn
• increased hemoglobin content_Cyp1a1<tm4.1Dwn>/Cyp1a1<tm4.1Dwn>
  http://metadb.riken.jp/0005564B6129X1Cyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41Dwn
• decreased hematocrit_Cyp1a1<tm4.1Dwn>/Cyp1a1<tm4.1Dwn>
  http://metadb.riken.jp/0000208B6129X1Cyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41Dwn
• increased susceptibility to weight loss_Cyp1a1<tm1.1Dwn>/Cyp1a1<tm1.1Dwn>
  http://metadb.riken.jp/0010180B6129P2Cyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11Dwn
• decreased thymus weight_Cyp1a1<tm1.1Dwn>/Cyp1a1<tm1.1Dwn>
  http://metadb.riken.jp/0004956B6129P2Cyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11Dwn
• increased circulating alanine transaminase level_Cyp1a1<tm4.1Dwn>/Cyp1a1<tm4.1Dwn>
  http://metadb.riken.jp/0002941B6129X1Cyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41Dwn
• increased circulating aspartate transaminase level_Cyp1a1<tm4.1Dwn>/Cyp1a1<tm4.1Dwn>
  http://metadb.riken.jp/0005343B6129X1Cyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41Dwn
• decreased lymphocyte cell number_Cyp1a1<tm4.1Dwn>/Cyp1a1<tm4.1Dwn>
  http://metadb.riken.jp/0005016B6129X1Cyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41DwnCyp1a1tm41Dwn
• abnormal hemoglobin content_Cyp1a1<tm1.1Dwn>/Cyp1a1<tm1.1Dwn>
  http://metadb.riken.jp/0005563B6129P2Cyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11DwnCyp1a1tm11Dwn

class

http://purl.org/net/cito/citesAsAuthority

• Cyp1a1<tm3.1Dwn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4830523
• Cyp1a1<tm4.1Dwn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4830524
• Cyp1a1<tm2.1Dwn>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4830522