increased physiological sensitivity to xenobiotic_Mt1<tm1Rch>/Mt1<tm1Rch>,Mt2<tm1Rch>/Mt2<tm1Rch>

http://metadb.riken.jp/0008873I129P2OlaHsdC57BL6JMt1tm1RchMt1tm1RchMt2tm1RchMt2tm1RchMt2tm1RchMt1tm1Rch

increased physiological sensitivity to xenobiotic_Mt1<tm1Rch>/Mt1<tm1Rch>,Mt2<tm1Rch>/Mt2<tm1Rch>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• metallothionein 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97171
• metallothionein 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:97172

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Mt1<tm1Rch>/Mt1<tm1Rch>,Mt2<tm1Rch>/Mt2<tm1Rch>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Mt2<tm1Rch>|Mt1<tm1Rch>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased physiological sensitivity to xenobiotic
  http://purl.obolibrary.org/obo/MP_0008873

文献

http://purl.org/net/cito/citesAsAuthority

• J. Liu, et.al., Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity., The Journal of pharmacology and experimental therapeutics, 1999, 289
  http://rdf.ncbi.nlm.nih.gov/pubmed/10087053