increased physiological sensitivity to xenobiotic_Cyp3a13<tm1Ahs>/Cyp3a13<tm1Ahs>,Del(5Cyp3a57-Cyp3a59)1Ahs/Del(5Cyp3a57-Cyp3a59)1Ahs

http://metadb.riken.jp/0008873I129P2OlaHsdFVBNCyp3a13tm1AhsCyp3a13tm1AhsDel5Cyp3a57Cyp3a591AhsDel5Cyp3a57Cyp3a591AhsDel5Cyp3a57Cyp3a591AhsCyp3a13tm1Ahs

increased physiological sensitivity to xenobiotic_Cyp3a13<tm1Ahs>/Cyp3a13<tm1Ahs>,Del(5Cyp3a57-Cyp3a59)1Ahs/Del(5Cyp3a57-Cyp3a59)1Ahs

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• cytochrome P450, family 3, subfamily a, polypeptide 13
  http://metadb.riken.jp/db/mgi_rdf/MGI:88610
• deletion, Chr 5, Alfred H Schinkel 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:3775603

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cyp3a13<tm1Ahs>/Cyp3a13<tm1Ahs>,Del(5Cyp3a57-Cyp3a59)1Ahs/Del(5Cyp3a57-Cyp3a59)1Ahs

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Del(5Cyp3a57-Cyp3a59)1Ahs|Cyp3a13<tm1Ahs>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased physiological sensitivity to xenobiotic
  http://purl.obolibrary.org/obo/MP_0008873

文献

http://purl.org/net/cito/citesAsAuthority

• Antonius E. van Herwaarden, et.al., Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism., The Journal of clinical investigation, 2007, 117
  http://rdf.ncbi.nlm.nih.gov/pubmed/17975676