Antonius E. van Herwaarden, et.al., Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism., The Journal of clinical investigation, 2007, 117

http://rdf.ncbi.nlm.nih.gov/pubmed/17975676

Antonius E. van Herwaarden, et.al., Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism., The Journal of clinical investigation, 2007, 117

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Cyp3a59<tm1Ahs>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3775600
• Cyp3a57<tm1Ahs>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3775599
• Tg(Vil1-CYP3A4)1Ahs
  http://metadb.riken.jp/db/mgi_rdf/MGI:3775624
• Cyp3a13<tm1Ahs>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3764486
• Del(5Cyp3a57-Cyp3a59)1Ahs
  http://metadb.riken.jp/db/mgi_rdf/MGI:3775604

class

http://purl.org/net/cito/citesAsAuthority

• Cyp3a59<tm1Ahs>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3775600
• Cyp3a57<tm1Ahs>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3775599
• Tg(Vil1-CYP3A4)1Ahs
  http://metadb.riken.jp/db/mgi_rdf/MGI:3775624
• Cyp3a13<tm1Ahs>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3764486
• Del(5Cyp3a57-Cyp3a59)1Ahs
  http://metadb.riken.jp/db/mgi_rdf/MGI:3775604

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased sensitivity to xenobiotic induced morbidity/mortality_Cyp3a13<tm1Ahs>/Cyp3a13<tm1Ahs>,Del(5Cyp3a57-Cyp3a59)1Ahs/Del(5Cyp3a57-Cyp3a59)1Ahs
  http://metadb.riken.jp/0009766I129P2OlaHsdFVBNCyp3a13tm1AhsCyp3a13tm1AhsDel5Cyp3a57Cyp3a591AhsDel5Cyp3a57Cyp3a591AhsDel5Cyp3a57Cyp3a591AhsCyp3a13tm1Ahs
• abnormal xenobiotic pharmacokinetics_Cyp3a13<tm1Ahs>/Cyp3a13<tm1Ahs>,Del(5Cyp3a57-Cyp3a59)1Ahs/Del(5Cyp3a57-Cyp3a59)1Ahs
  http://metadb.riken.jp/0008875I129P2OlaHsdFVBNCyp3a13tm1AhsCyp3a13tm1AhsDel5Cyp3a57Cyp3a591AhsDel5Cyp3a57Cyp3a591AhsDel5Cyp3a57Cyp3a591AhsCyp3a13tm1Ahs
• abnormal xenobiotic pharmacokinetics_Cyp3a13<tm1Ahs>/Cyp3a13<tm1Ahs>,Del(5Cyp3a57-Cyp3a59)1Ahs/Del(5Cyp3a57-Cyp3a59)1Ahs,Tg(APOE-CYP3A4)A1Ahs/0
  http://metadb.riken.jp/0008875I129P2OlaHsdFVBNCyp3a13tm1AhsCyp3a13tm1AhsDel5Cyp3a57Cyp3a591AhsDel5Cyp3a57Cyp3a591AhsTgAPOECYP3A4A1Ahs0Cyp3a13tm1AhsTgAPOECYP3A4A1AhsDel5Cyp3a57Cyp3a591Ahs
• no abnormal phenotype detected_Del(5Cyp3a57-Cyp3a59)1Ahs/Del(5Cyp3a57-Cyp3a59)1Ahs
  http://metadb.riken.jp/0002169I129P2OlaHsdDel5Cyp3a57Cyp3a591AhsDel5Cyp3a57Cyp3a591AhsDel5Cyp3a57Cyp3a591Ahs
• increased physiological sensitivity to xenobiotic_Cyp3a13<tm1Ahs>/Cyp3a13<tm1Ahs>,Del(5Cyp3a57-Cyp3a59)1Ahs/Del(5Cyp3a57-Cyp3a59)1Ahs
  http://metadb.riken.jp/0008873I129P2OlaHsdFVBNCyp3a13tm1AhsCyp3a13tm1AhsDel5Cyp3a57Cyp3a591AhsDel5Cyp3a57Cyp3a591AhsDel5Cyp3a57Cyp3a591AhsCyp3a13tm1Ahs
• abnormal xenobiotic pharmacokinetics_Cyp3a13<tm1Ahs>/Cyp3a13<tm1Ahs>,Del(5Cyp3a57-Cyp3a59)1Ahs/Del(5Cyp3a57-Cyp3a59)1Ahs,Tg(Vil1-CYP3A4)1Ahs/0
  http://metadb.riken.jp/0008875I129P2OlaHsdFVBNCyp3a13tm1AhsCyp3a13tm1AhsDel5Cyp3a57Cyp3a591AhsDel5Cyp3a57Cyp3a591AhsTgVil1CYP3A41Ahs0Del5Cyp3a57Cyp3a591AhsCyp3a13tm1AhsTgVil1CYP3A41Ahs
• no abnormal phenotype detected_Cyp3a13<tm1Ahs>/Cyp3a13<tm1Ahs>
  http://metadb.riken.jp/0002169I129P2OlaHsdFVBCyp3a13tm1AhsCyp3a13tm1AhsCyp3a13tm1Ahs
• abnormal intestinal mucosa morphology_Tg(Vil1-CYP3A4)1Ahs/0
  http://metadb.riken.jp/0000511IFVBNTgVil1CYP3A41Ahs0TgVil1CYP3A41Ahs