increased physiological sensitivity to xenobiotic_Fan1<tm1.1Jrou>/Fan1<tm1.1Jrou>,Slx4<tm1.2Jrou>/Slx4<tm1.2Jrou>

http://metadb.riken.jp/0008873I129P2OlaHsdFan1tm11JrouFan1tm11JrouSlx4tm12JrouSlx4tm12JrouSlx4tm12JrouFan1tm11Jrou

increased physiological sensitivity to xenobiotic_Fan1<tm1.1Jrou>/Fan1<tm1.1Jrou>,Slx4<tm1.2Jrou>/Slx4<tm1.2Jrou>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
  http://metadb.riken.jp/db/mgi_rdf/MGI:106299
• FANCD2/FANCI-associated nuclease 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:3045266

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Fan1<tm1.1Jrou>/Fan1<tm1.1Jrou>,Slx4<tm1.2Jrou>/Slx4<tm1.2Jrou>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Slx4<tm1.2Jrou>|Fan1<tm1.1Jrou>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased physiological sensitivity to xenobiotic
  http://purl.obolibrary.org/obo/MP_0008873

文献

http://purl.org/net/cito/citesAsAuthority

• Christophe. Lachaud, et.al., Karyomegalic interstitial nephritis and DNA damage-induced polyploidy in Fan1 nuclease-defective knock-in mice., Genes & development, 2016, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/26980188