increased physiological sensitivity to xenobiotic_Fan1<tm1d(KOMP)Wtsi>/Fan1<tm1d(KOMP)Wtsi>,Mus81<tm1Chmg>/Mus81<tm1Chmg>

http://metadb.riken.jp/0008873I129S5SvEvBrdC57BL6NFVBNFan1tm1dKOMPWtsiFan1tm1dKOMPWtsiMus81tm1ChmgMus81tm1ChmgFan1tm1dKOMPWtsiMus81tm1Chmg

increased physiological sensitivity to xenobiotic_Fan1<tm1d(KOMP)Wtsi>/Fan1<tm1d(KOMP)Wtsi>,Mus81<tm1Chmg>/Mus81<tm1Chmg>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• FANCD2/FANCI-associated nuclease 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:3045266
• MUS81 structure-specific endonuclease subunit
  http://metadb.riken.jp/db/mgi_rdf/MGI:1918961

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Fan1<tm1d(KOMP)Wtsi>/Fan1<tm1d(KOMP)Wtsi>,Mus81<tm1Chmg>/Mus81<tm1Chmg>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Fan1<tm1d(KOMP)Wtsi>|Mus81<tm1Chmg>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S5/SvEvBrd * C57BL/6N * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased physiological sensitivity to xenobiotic
  http://purl.obolibrary.org/obo/MP_0008873

文献

http://purl.org/net/cito/citesAsAuthority

• Supawat. Thongthip, et.al., Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction., Genes & development, 2016, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/26980189