Supawat. Thongthip, et.al., Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction., Genes & development, 2016, 30

http://rdf.ncbi.nlm.nih.gov/pubmed/26980189

Supawat. Thongthip, et.al., Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction., Genes & development, 2016, 30

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Fan1<tm1d(KOMP)Wtsi>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5796264
• Fan1<tm1c(KOMP)Wtsi>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5796185

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased sensitivity to xenobiotic induced morbidity/mortality_Fan1<tm1d(KOMP)Wtsi>/Fan1<tm1d(KOMP)Wtsi>
  http://metadb.riken.jp/0009766IC57BL6NFVBNFan1tm1dKOMPWtsiFan1tm1dKOMPWtsiFan1tm1dKOMPWtsi
• abnormal hematopoietic stem cell physiology_Fan1<tm1d(KOMP)Wtsi>/Fan1<tm1d(KOMP)Wtsi>
  http://metadb.riken.jp/0010763IC57BL6NFVBNFan1tm1dKOMPWtsiFan1tm1dKOMPWtsiFan1tm1dKOMPWtsi
• increased physiological sensitivity to xenobiotic_Fan1<tm1d(KOMP)Wtsi>/Fan1<tm1d(KOMP)Wtsi>
  http://metadb.riken.jp/0008873IC57BL6NFVBNFan1tm1dKOMPWtsiFan1tm1dKOMPWtsiFan1tm1dKOMPWtsi
• abnormal cell nucleus morphology_Fan1<tm1d(KOMP)Wtsi>/Fan1<tm1d(KOMP)Wtsi>
  http://metadb.riken.jp/0003111IC57BL6NFVBNFan1tm1dKOMPWtsiFan1tm1dKOMPWtsiFan1tm1dKOMPWtsi
• increased physiological sensitivity to xenobiotic_Fan1<tm1d(KOMP)Wtsi>/Fan1<tm1d(KOMP)Wtsi>,Mus81<tm1Chmg>/Mus81<tm1Chmg>
  http://metadb.riken.jp/0008873I129S5SvEvBrdC57BL6NFVBNFan1tm1dKOMPWtsiFan1tm1dKOMPWtsiMus81tm1ChmgMus81tm1ChmgFan1tm1dKOMPWtsiMus81tm1Chmg
• increased physiological sensitivity to xenobiotic_Fan1<tm1d(KOMP)Wtsi>/Fan1<tm1d(KOMP)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0008873I129S4SvJaeC57BL6NFVBNFan1tm1dKOMPWtsiFan1tm1dKOMPWtsiFancd2tm1HouFancd2tm1HouFan1tm1dKOMPWtsiFancd2tm1Hou
• increased physiological sensitivity to xenobiotic_Mus81<tm1Chmg>/Mus81<tm1Chmg>
  http://metadb.riken.jp/0008873I129S5SvEvBrdMus81tm1ChmgMus81tm1ChmgMus81tm1Chmg
• increased hepatocyte karyomegaly_Fan1<tm1d(KOMP)Wtsi>/Fan1<tm1d(KOMP)Wtsi>
  http://metadb.riken.jp/0020427IC57BL6NFVBNFan1tm1dKOMPWtsiFan1tm1dKOMPWtsiFan1tm1dKOMPWtsi
• abnormal renal tubule morphology_Fan1<tm1d(KOMP)Wtsi>/Fan1<tm1d(KOMP)Wtsi>
  http://metadb.riken.jp/0002703IC57BL6NFVBNFan1tm1dKOMPWtsiFan1tm1dKOMPWtsiFan1tm1dKOMPWtsi
• abnormal hematopoietic stem cell morphology_Fan1<tm1d(KOMP)Wtsi>/Fan1<tm1d(KOMP)Wtsi>,Fancd2<tm1Hou>/Fancd2<tm1Hou>
  http://metadb.riken.jp/0004808I129S4SvJaeC57BL6NFVBNFan1tm1dKOMPWtsiFan1tm1dKOMPWtsiFancd2tm1HouFancd2tm1HouFan1tm1dKOMPWtsiFancd2tm1Hou
• decreased liver function_Fan1<tm1d(KOMP)Wtsi>/Fan1<tm1d(KOMP)Wtsi>
  http://metadb.riken.jp/0003325IC57BL6NFVBNFan1tm1dKOMPWtsiFan1tm1dKOMPWtsiFan1tm1dKOMPWtsi
• polyploidy_Fan1<tm1d(KOMP)Wtsi>/Fan1<tm1d(KOMP)Wtsi>
  http://metadb.riken.jp/0004025IC57BL6NFVBNFan1tm1dKOMPWtsiFan1tm1dKOMPWtsiFan1tm1dKOMPWtsi

class

http://purl.org/net/cito/citesAsAuthority

• Fan1<tm1d(KOMP)Wtsi>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5796264
• Fan1<tm1c(KOMP)Wtsi>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5796185