decreased physiological sensitivity to xenobiotic_Grk2<tm1Gwd>/Grk2<tm1Gwd>,Nkx2-5<tm1(cre)Rjs>/Nkx2-5<+>

http://metadb.riken.jp/0008874I129S4SvJaeSor129S7SvEvBrdC57BL6Grk2tm1GwdGrk2tm1GwdNkx25tm1creRjsNkx25Nkx25Grk2tm1GwdNkx25tm1creRjs

decreased physiological sensitivity to xenobiotic_Grk2<tm1Gwd>/Grk2<tm1Gwd>,Nkx2-5<tm1(cre)Rjs>/Nkx2-5<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• NK2 homeobox 5
  http://metadb.riken.jp/db/mgi_rdf/MGI:97350
• G protein-coupled receptor kinase 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:87940

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Grk2<tm1Gwd>/Grk2<tm1Gwd>,Nkx2-5<tm1(cre)Rjs>/Nkx2-5<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Nkx2-5<+>|Grk2<tm1Gwd>|Nkx2-5<tm1(cre)Rjs>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased physiological sensitivity to xenobiotic
  http://purl.obolibrary.org/obo/MP_0008874

文献

http://purl.org/net/cito/citesAsAuthority

• Scot J. Matkovich, et.al., Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling., Circulation research, 2006, 99
  http://rdf.ncbi.nlm.nih.gov/pubmed/17008600