abnormal xenobiotic pharmacokinetics_Cyp3a13<tm1Ahs>/Cyp3a13<tm1Ahs>,Del(5Cyp3a57-Cyp3a59)1Ahs/Del(5Cyp3a57-Cyp3a59)1Ahs,Tg(APOE-CYP3A4)A1Ahs/0

http://metadb.riken.jp/0008875I129P2OlaHsdFVBNCyp3a13tm1AhsCyp3a13tm1AhsDel5Cyp3a57Cyp3a591AhsDel5Cyp3a57Cyp3a591AhsTgAPOECYP3A4A1Ahs0Cyp3a13tm1AhsTgAPOECYP3A4A1AhsDel5Cyp3a57Cyp3a591Ahs

abnormal xenobiotic pharmacokinetics_Cyp3a13<tm1Ahs>/Cyp3a13<tm1Ahs>,Del(5Cyp3a57-Cyp3a59)1Ahs/Del(5Cyp3a57-Cyp3a59)1Ahs,Tg(APOE-CYP3A4)A1Ahs/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• deletion, Chr 5, Alfred H Schinkel 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:3775603
• transgene insertion A1, Alfred H Schinkel
  http://metadb.riken.jp/db/mgi_rdf/MGI:3775619
• cytochrome P450, family 3, subfamily a, polypeptide 13
  http://metadb.riken.jp/db/mgi_rdf/MGI:88610

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cyp3a13<tm1Ahs>/Cyp3a13<tm1Ahs>,Del(5Cyp3a57-Cyp3a59)1Ahs/Del(5Cyp3a57-Cyp3a59)1Ahs,Tg(APOE-CYP3A4)A1Ahs/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cyp3a13<tm1Ahs>|Tg(APOE-CYP3A4)A1Ahs|Del(5Cyp3a57-Cyp3a59)1Ahs

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal xenobiotic pharmacokinetics
  http://purl.obolibrary.org/obo/MP_0008875

文献

http://purl.org/net/cito/citesAsAuthority

• Antonius E. van Herwaarden, et.al., Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism., The Journal of clinical investigation, 2007, 117
  http://rdf.ncbi.nlm.nih.gov/pubmed/17975676