decreased neuron number_Agrp<tm2(DTR)Rpa>/Agrp<+>,Lep<ob>/Lep<ob>

http://metadb.riken.jp/0008948I129S4SvJaeSorC57BL6Agrptm2DTRRpaAgrpLepobLepobAgrpAgrptm2DTRRpaLepob

decreased neuron number_Agrp<tm2(DTR)Rpa>/Agrp<+>,Lep<ob>/Lep<ob>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• agouti related neuropeptide
  http://metadb.riken.jp/db/mgi_rdf/MGI:892013
• leptin
  http://metadb.riken.jp/db/mgi_rdf/MGI:104663

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Agrp<tm2(DTR)Rpa>/Agrp<+>,Lep<ob>/Lep<ob>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Agrp<+>|Agrp<tm2(DTR)Rpa>|Lep<ob>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJaeSor * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased neuron number
  http://purl.obolibrary.org/obo/MP_0008948

文献

http://purl.org/net/cito/citesAsAuthority

• Qi. Wu, et.al., Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility., Proceedings of the National Academy of Sciences of the United States of America, 2012, 109
  http://rdf.ncbi.nlm.nih.gov/pubmed/22232663