Qi. Wu, et.al., Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility., Proceedings of the National Academy of Sciences of the United States of America, 2012, 109

http://rdf.ncbi.nlm.nih.gov/pubmed/22232663

Qi. Wu, et.al., Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility., Proceedings of the National Academy of Sciences of the United States of America, 2012, 109

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Pmch<tm1.1(DTR)Rpa>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5319632

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal eating behavior_Agrp<tm2(DTR)Rpa>/Agrp<+>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0001431I129S4SvJaeSorC57BL6Agrptm2DTRRpaAgrpLepobLepobAgrpAgrptm2DTRRpaLepob
• increased sensitivity to induced morbidity/mortality_Agrp<tm2(DTR)Rpa>/Agrp<+>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0009763I129S4SvJaeSorC57BL6Agrptm2DTRRpaAgrpLepobLepobAgrpAgrptm2DTRRpaLepob
• weight loss_Agrp<tm2(DTR)Rpa>/Agrp<+>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0001263I129S4SvJaeSorC57BL6Agrptm2DTRRpaAgrpLepobLepobAgrpAgrptm2DTRRpaLepob
• decreased body temperature_Agrp<tm2(DTR)Rpa>/Agrp<+>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0005534I129S4SvJaeSorC57BL6Agrptm2DTRRpaAgrpLepobLepobAgrpAgrptm2DTRRpaLepob
• abnormal postnatal growth_Lep<ob>/Lep<ob>,Pmch<tm1.1(DTR)Rpa>/Pmch<+>
  http://metadb.riken.jp/0001731B6CgLepobPmchtm11DTRRpaLepobLepobPmchtm11DTRRpaPmchPmchPmchtm11DTRRpaLepob
• reduced male fertility_Lep<ob>/Lep<ob>,Pmch<tm1.1(DTR)Rpa>/Pmch<+>
  http://metadb.riken.jp/0001922B6CgLepobPmchtm11DTRRpaLepobLepobPmchtm11DTRRpaPmchPmchPmchtm11DTRRpaLepob
• enhanced fertility_Agrp<tm2(DTR)Rpa>/Agrp<+>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0010143I129S4SvJaeSorC57BL6Agrptm2DTRRpaAgrpLepobLepobAgrpAgrptm2DTRRpaLepob
• improved glucose tolerance_Lep<ob>/Lep<ob>,Pmch<tm1.1(DTR)Rpa>/Pmch<+>
  http://metadb.riken.jp/0005292B6CgLepobPmchtm11DTRRpaLepobLepobPmchtm11DTRRpaPmchPmchPmchtm11DTRRpaLepob
• improved glucose tolerance_Agrp<tm2(DTR)Rpa>/Agrp<+>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0005292I129S4SvJaeSorC57BL6Agrptm2DTRRpaAgrpLepobLepobAgrpAgrptm2DTRRpaLepob
• decreased body weight_Agrp<tm2(DTR)Rpa>/Agrp<+>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0001262I129S4SvJaeSorC57BL6Agrptm2DTRRpaAgrpLepobLepobAgrpAgrptm2DTRRpaLepob
• decreased neuron number_Lep<ob>/Lep<ob>,Pmch<tm1.1(DTR)Rpa>/Pmch<+>
  http://metadb.riken.jp/0008948B6CgLepobPmchtm11DTRRpaLepobLepobPmchtm11DTRRpaPmchPmchPmchtm11DTRRpaLepob
• female infertility_Lep<ob>/Lep<ob>,Pmch<tm1.1(DTR)Rpa>/Pmch<+>
  http://metadb.riken.jp/0001926B6CgLepobPmchtm11DTRRpaLepobLepobPmchtm11DTRRpaPmchPmchPmchtm11DTRRpaLepob
• decreased neuron number_Agrp<tm2(DTR)Rpa>/Agrp<+>,Lep<ob>/Lep<ob>
  http://metadb.riken.jp/0008948I129S4SvJaeSorC57BL6Agrptm2DTRRpaAgrpLepobLepobAgrpAgrptm2DTRRpaLepob
• decreased body weight_Lep<ob>/Lep<ob>,Pmch<tm1.1(DTR)Rpa>/Pmch<+>
  http://metadb.riken.jp/0001262B6CgLepobPmchtm11DTRRpaLepobLepobPmchtm11DTRRpaPmchPmchPmchtm11DTRRpaLepob

class

http://purl.org/net/cito/citesAsAuthority

• Pmch<tm1.1(DTR)Rpa>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5319632