decreased neuron number_Nhlh2<tm2Thbr>/Nhlh2<tm2Thbr>,Tg(Gnrh1-cre)1Dlc/0,Tg(Pomc-EGFP)1Low/0

http://metadb.riken.jp/0008948I129S7SvEvBrdC57BL6C57BL6JCBANhlh2tm2ThbrNhlh2tm2ThbrTgGnrh1cre1Dlc0TgPomcEGFP1Low0Nhlh2tm2ThbrTgPomcEGFP1LowTgGnrh1cre1Dlc

decreased neuron number_Nhlh2<tm2Thbr>/Nhlh2<tm2Thbr>,Tg(Gnrh1-cre)1Dlc/0,Tg(Pomc-EGFP)1Low/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1, Malcolm J Low
  http://metadb.riken.jp/db/mgi_rdf/MGI:3776090
• nescient helix loop helix 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:97324
• transgene insertion 1, Catherine Dulac
  http://metadb.riken.jp/db/mgi_rdf/MGI:3804662

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Nhlh2<tm2Thbr>/Nhlh2<tm2Thbr>,Tg(Gnrh1-cre)1Dlc/0,Tg(Pomc-EGFP)1Low/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Nhlh2<tm2Thbr>|Tg(Pomc-EGFP)1Low|Tg(Gnrh1-cre)1Dlc

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased neuron number
  http://purl.obolibrary.org/obo/MP_0008948

文献

http://purl.org/net/cito/citesAsAuthority

• Thomas. Schmid, et.al., Loss of NSCL-2 in gonadotropin releasing hormone neurons leads to reduction of pro-opiomelanocortin neurons in specific hypothalamic nuclei and causes visceral obesity., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, 33
  http://rdf.ncbi.nlm.nih.gov/pubmed/23785158