decreased erythroid progenitor cell number_Epas1<tm1Mcs>/Epas1<tm1Mcs>,Hif1a<tm3Rsjo>/Hif1a<tm3Rsjo>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0

http://metadb.riken.jp/0008973I129S1Sv129X1SvJCD1Epas1tm1McsEpas1tm1McsHif1atm3RsjoHif1atm3RsjoTgSp7tTAtetOEGFPcre1Amc0Epas1tm1McsTgSp7tTAtetOEGFPcre1AmcHif1atm3Rsjo

decreased erythroid progenitor cell number_Epas1<tm1Mcs>/Epas1<tm1Mcs>,Hif1a<tm3Rsjo>/Hif1a<tm3Rsjo>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• endothelial PAS domain protein 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:109169
• transgene insertion 1, Andrew P McMahon
  http://metadb.riken.jp/db/mgi_rdf/MGI:3689349
• hypoxia inducible factor 1, alpha subunit
  http://metadb.riken.jp/db/mgi_rdf/MGI:106918

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Epas1<tm1Mcs>/Epas1<tm1Mcs>,Hif1a<tm3Rsjo>/Hif1a<tm3Rsjo>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Epas1<tm1Mcs>|Tg(Sp7-tTA,tetO-EGFP/cre)1Amc|Hif1a<tm3Rsjo>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ * CD-1

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased erythroid progenitor cell number
  http://purl.obolibrary.org/obo/MP_0008973

文献

http://purl.org/net/cito/citesAsAuthority

• Erinn B. Rankin, et.al., The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO., Cell, 2012, 149
  http://rdf.ncbi.nlm.nih.gov/pubmed/22464323