Erinn B. Rankin, et.al., The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO., Cell, 2012, 149

http://rdf.ncbi.nlm.nih.gov/pubmed/22464323

Erinn B. Rankin, et.al., The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO., Cell, 2012, 149

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased hematocrit_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0002608I129S4SvJaeCD1Vhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcVhltm1Jae
• increased osteoblast cell number_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0004988I129S4SvJaeCD1Vhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcVhltm1Jae
• polycythemia_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0002872I129S4SvJaeCD1Vhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcVhltm1Jae
• decreased erythroid progenitor cell number_Epas1<tm1Mcs>/Epas1<tm1Mcs>,Hif1a<tm3Rsjo>/Hif1a<tm3Rsjo>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0008973I129S1Sv129X1SvJCD1Epas1tm1McsEpas1tm1McsHif1atm3RsjoHif1atm3RsjoTgSp7tTAtetOEGFPcre1Amc0Epas1tm1McsTgSp7tTAtetOEGFPcre1AmcHif1atm3Rsjo
• decreased bone marrow cell number_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0000333I129S4SvJaeCD1Vhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcVhltm1Jae
• decreased trabecular bone volume_Epas1<tm1Mcs>/Epas1<tm1Mcs>,Hif1a<tm3Rsjo>/Hif1a<tm3Rsjo>,Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0010879I129S1Sv129S4SvJae129X1SvJCD1Epas1tm1McsEpas1tm1McsHif1atm3RsjoHif1atm3RsjoVhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcHif1atm3RsjoVhltm1JaeEpas1tm1Mcs
• decreased circulating erythropoietin level_Epas1<tm1Mcs>/Epas1<tm1Mcs>,Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0011286I129S4SvJae129X1SvJCD1Epas1tm1McsEpas1tm1McsVhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0Vhltm1JaeEpas1tm1McsTgSp7tTAtetOEGFPcre1Amc
• increased hematopoietic stem cell number_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0004809I129S4SvJaeCD1Vhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcVhltm1Jae
• decreased erythroid progenitor cell number_Epas1<tm1Mcs>/Epas1<tm1Mcs>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0008973I129S1Sv129X1SvJCD1Epas1tm1McsEpas1tm1McsTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcEpas1tm1Mcs
• increased erythrocyte cell number_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0003131I129S4SvJaeCD1Vhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcVhltm1Jae
• increased trabecular bone mass_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0010872I129S4SvJaeCD1Vhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcVhltm1Jae
• extramedullary hematopoiesis_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0000240I129S4SvJaeCD1Vhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcVhltm1Jae
• abnormal angiogenesis_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0000260I129S4SvJaeCD1Vhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcVhltm1Jae
• decreased body size_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0001265I129S4SvJaeCD1Vhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcVhltm1Jae
• increased circulating erythropoietin level_Hif1a<tm3Rsjo>/Hif1a<tm3Rsjo>,Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0011285I129S1Sv129S4SvJae129X1SvJCD1Hif1atm3RsjoHif1atm3RsjoVhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0Vhltm1JaeHif1atm3RsjoTgSp7tTAtetOEGFPcre1Amc
• increased circulating erythropoietin level_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0011285I129S4SvJaeCD1Vhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcVhltm1Jae
• decreased trabecular bone volume_Epas1<tm1Mcs>/Epas1<tm1Mcs>,Hif1a<tm3Rsjo>/Hif1a<tm3Rsjo>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0010879I129S1Sv129X1SvJCD1Epas1tm1McsEpas1tm1McsHif1atm3RsjoHif1atm3RsjoTgSp7tTAtetOEGFPcre1Amc0Epas1tm1McsTgSp7tTAtetOEGFPcre1AmcHif1atm3Rsjo
• increased trabecular bone volume_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0010878I129S4SvJaeCD1Vhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcVhltm1Jae
• decreased bone trabecula number_Epas1<tm1Mcs>/Epas1<tm1Mcs>,Hif1a<tm3Rsjo>/Hif1a<tm3Rsjo>,Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0010869I129S1Sv129S4SvJae129X1SvJCD1Epas1tm1McsEpas1tm1McsHif1atm3RsjoHif1atm3RsjoVhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcHif1atm3RsjoVhltm1JaeEpas1tm1Mcs
• abnormal blood cell morphology/development_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0002429I129S4SvJaeCD1Vhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcVhltm1Jae
• increased hematocrit_Egln1<tm2Fong>/Egln1<tm2Fong>,Egln2<tm2Fong>/Egln2<tm2Fong>,Egln3<tm2Fong>/Egln3<tm2Fong>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0002608I129S6SvEvTacC57BL6NCrCD1Egln1tm2FongEgln1tm2FongEgln2tm2FongEgln2tm2FongEgln3tm2FongEgln3tm2FongTgSp7tTAtetOEGFPcre1Amc0Egln2tm2FongEgln1tm2FongEgln3tm2FongTgSp7tTAtetOEGFPcre1Amc
• decreased lymphocyte cell number_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0005016I129S4SvJaeCD1Vhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcVhltm1Jae
• increased erythroid progenitor cell number_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0003135I129S4SvJaeCD1Vhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcVhltm1Jae
• decreased circulating erythropoietin level_Epas1<tm1Mcs>/Epas1<tm1Mcs>,Hif1a<tm3Rsjo>/Hif1a<tm3Rsjo>,Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0011286I129S1Sv129S4SvJae129X1SvJCD1Epas1tm1McsEpas1tm1McsHif1atm3RsjoHif1atm3RsjoVhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcHif1atm3RsjoVhltm1JaeEpas1tm1Mcs
• abnormal foot pad morphology_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0000574I129S4SvJaeCD1Vhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcVhltm1Jae
• enlarged spleen_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0000691I129S4SvJaeCD1Vhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcVhltm1Jae
• increased bone trabecula number_Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0010868I129S4SvJaeCD1Vhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0TgSp7tTAtetOEGFPcre1AmcVhltm1Jae
• increased hematocrit_Hif1a<tm3Rsjo>/Hif1a<tm3Rsjo>,Vhl<tm1Jae>/Vhl<tm1Jae>,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
  http://metadb.riken.jp/0002608I129S1Sv129S4SvJae129X1SvJCD1Hif1atm3RsjoHif1atm3RsjoVhltm1JaeVhltm1JaeTgSp7tTAtetOEGFPcre1Amc0Vhltm1JaeHif1atm3RsjoTgSp7tTAtetOEGFPcre1Amc