increased pancreatic beta cell mass_Gck<tm1Tka>/Gck<+>,Irs1<tm1Tka>/Irs1<tm1Tka>

http://metadb.riken.jp/0009113I129X1SvJC57BL6CBAICRGcktm1TkaGckIrs1tm1TkaIrs1tm1TkaGcktm1TkaGckIrs1tm1Tka

increased pancreatic beta cell mass_Gck<tm1Tka>/Gck<+>,Irs1<tm1Tka>/Irs1<tm1Tka>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• glucokinase
  http://metadb.riken.jp/db/mgi_rdf/MGI:1270854
• insulin receptor substrate 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:99454

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gck<tm1Tka>/Gck<+>,Irs1<tm1Tka>/Irs1<tm1Tka>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gck<tm1Tka>|Gck<+>|Irs1<tm1Tka>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129X1/SvJ * C57BL/6 * CBA * ICR

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pancreatic beta cell mass
  http://purl.obolibrary.org/obo/MP_0009113

文献

http://purl.org/net/cito/citesAsAuthority

• Y. Terauchi, et.al., Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease., The Journal of clinical investigation, 1997, 99
  http://rdf.ncbi.nlm.nih.gov/pubmed/9062343