Y. Terauchi, et.al., Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease., The Journal of clinical investigation, 1997, 99

http://rdf.ncbi.nlm.nih.gov/pubmed/9062343

Y. Terauchi, et.al., Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease., The Journal of clinical investigation, 1997, 99

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased body weight_Gck<tm1Tka>/Gck<+>,Irs1<tm1Tka>/Irs1<tm1Tka>
  http://metadb.riken.jp/0001262I129X1SvJC57BL6CBAICRGcktm1TkaGckIrs1tm1TkaIrs1tm1TkaGcktm1TkaGckIrs1tm1Tka
• postnatal growth retardation_Gck<tm1Tka>/Gck<+>,Irs1<tm1Tka>/Irs1<tm1Tka>
  http://metadb.riken.jp/0001732I129X1SvJC57BL6CBAICRGcktm1TkaGckIrs1tm1TkaIrs1tm1TkaGcktm1TkaGckIrs1tm1Tka
• increased circulating insulin level_Gck<tm1Tka>/Gck<+>,Irs1<tm1Tka>/Irs1<tm1Tka>
  http://metadb.riken.jp/0002079I129X1SvJC57BL6CBAICRGcktm1TkaGckIrs1tm1TkaIrs1tm1TkaGcktm1TkaGckIrs1tm1Tka
• impaired glucose tolerance_Gck<tm1Tka>/Gck<+>,Irs1<tm1Tka>/Irs1<tm1Tka>
  http://metadb.riken.jp/0005293I129X1SvJC57BL6CBAICRGcktm1TkaGckIrs1tm1TkaIrs1tm1TkaGcktm1TkaGckIrs1tm1Tka
• insulin resistance_Gck<tm1Tka>/Gck<+>,Irs1<tm1Tka>/Irs1<tm1Tka>
  http://metadb.riken.jp/0005331I129X1SvJC57BL6CBAICRGcktm1TkaGckIrs1tm1TkaIrs1tm1TkaGcktm1TkaGckIrs1tm1Tka
• pancreatic islet hyperplasia_Gck<tm1Tka>/Gck<+>,Irs1<tm1Tka>/Irs1<tm1Tka>
  http://metadb.riken.jp/0005491I129X1SvJC57BL6CBAICRGcktm1TkaGckIrs1tm1TkaIrs1tm1TkaGcktm1TkaGckIrs1tm1Tka
他1件を見る
• increased pancreatic beta cell mass_Gck<tm1Tka>/Gck<+>,Irs1<tm1Tka>/Irs1<tm1Tka>
  http://metadb.riken.jp/0009113I129X1SvJC57BL6CBAICRGcktm1TkaGckIrs1tm1TkaIrs1tm1TkaGcktm1TkaGckIrs1tm1Tka