decreased pancreatic beta cell mass_Wfs1<tm1Perm>/Wfs1<tm1Perm>,Tg(Ins2-cre)23Herr/0

http://metadb.riken.jp/0009114I129X1SvJC57BL6JCBAJWfs1tm1PermWfs1tm1PermTgIns2cre23Herr0Wfs1tm1PermTgIns2cre23Herr

decreased pancreatic beta cell mass_Wfs1<tm1Perm>/Wfs1<tm1Perm>,Tg(Ins2-cre)23Herr/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 23, Pedro Luis Herrera
  http://metadb.riken.jp/db/mgi_rdf/MGI:4431238
• wolframin ER transmembrane glycoprotein
  http://metadb.riken.jp/db/mgi_rdf/MGI:1328355

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Wfs1<tm1Perm>/Wfs1<tm1Perm>,Tg(Ins2-cre)23Herr/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Wfs1<tm1Perm>|Tg(Ins2-cre)23Herr

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129X1/SvJ * C57BL/6J * CBA/J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased pancreatic beta cell mass
  http://purl.obolibrary.org/obo/MP_0009114

文献

http://purl.org/net/cito/citesAsAuthority

• A C. Riggs, et.al., Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis., Diabetologia, 2005, 48
  http://rdf.ncbi.nlm.nih.gov/pubmed/16215705