A C. Riggs, et.al., Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis., Diabetologia, 2005, 48

http://rdf.ncbi.nlm.nih.gov/pubmed/16215705

A C. Riggs, et.al., Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis., Diabetologia, 2005, 48

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Wfs1<tm1Perm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3613056

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal pancreatic islet morphology_Wfs1<tm1Perm>/Wfs1<tm1Perm>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0005215I129X1SvJC57BL6JCBAJWfs1tm1PermWfs1tm1PermTgIns2cre23Herr0Wfs1tm1PermTgIns2cre23Herr
• decreased pancreatic beta cell mass_Wfs1<tm1Perm>/Wfs1<tm1Perm>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0009114I129X1SvJC57BL6JCBAJWfs1tm1PermWfs1tm1PermTgIns2cre23Herr0Wfs1tm1PermTgIns2cre23Herr
• decreased pancreatic beta cell number_Wfs1<tm1Perm>/Wfs1<tm1Perm>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0003339I129X1SvJC57BL6JCBAJWfs1tm1PermWfs1tm1PermTgIns2cre23Herr0Wfs1tm1PermTgIns2cre23Herr
• disorganized pancreatic islets_Wfs1<tm1Perm>/Wfs1<tm1Perm>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0009254I129X1SvJC57BL6JCBAJWfs1tm1PermWfs1tm1PermTgIns2cre23Herr0Wfs1tm1PermTgIns2cre23Herr
• abnormal pancreatic beta cell physiology_Wfs1<tm1Perm>/Wfs1<tm1Perm>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0003562I129X1SvJC57BL6JCBAJWfs1tm1PermWfs1tm1PermTgIns2cre23Herr0Wfs1tm1PermTgIns2cre23Herr
• impaired glucose tolerance_Wfs1<tm1Perm>/Wfs1<tm1Perm>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0005293I129X1SvJC57BL6JCBAJWfs1tm1PermWfs1tm1PermTgIns2cre23Herr0Wfs1tm1PermTgIns2cre23Herr
• abnormal glucose homeostasis_Wfs1<tm1Perm>/Wfs1<tm1Perm>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0002078I129X1SvJC57BL6JCBAJWfs1tm1PermWfs1tm1PermTgIns2cre23Herr0Wfs1tm1PermTgIns2cre23Herr
• decreased insulin secretion_Wfs1<tm1Perm>/Wfs1<tm1Perm>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0003059I129X1SvJC57BL6JCBAJWfs1tm1PermWfs1tm1PermTgIns2cre23Herr0Wfs1tm1PermTgIns2cre23Herr
• decreased body weight_Wfs1<tm1Perm>/Wfs1<tm1Perm>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0001262I129X1SvJC57BL6JCBAJWfs1tm1PermWfs1tm1PermTgIns2cre23Herr0Wfs1tm1PermTgIns2cre23Herr
• decreased circulating insulin level_Wfs1<tm1Perm>/Wfs1<tm1Perm>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0002727I129X1SvJC57BL6JCBAJWfs1tm1PermWfs1tm1PermTgIns2cre23Herr0Wfs1tm1PermTgIns2cre23Herr
• hyperglycemia_Wfs1<tm1Perm>/Wfs1<tm1Perm>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0001559I129X1SvJC57BL6JCBAJWfs1tm1PermWfs1tm1PermTgIns2cre23Herr0Wfs1tm1PermTgIns2cre23Herr

class

http://purl.org/net/cito/citesAsAuthority

• Wfs1<tm1Perm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3613056