increased pancreatic ductal adenocarcinoma incidence_Cdkn2a<tm4Rdp>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>

http://metadb.riken.jp/0009151I129FVBNCdkn2atm4RdpCdkn2aKrastm4TyjKrasSmad4tm1RdpSmad4tm1RdpPtf1atm11creCvwPtf1aPtf1aKrastm4TyjSmad4tm1RdpKrasCdkn2aCdkn2atm4RdpPtf1atm11creCvw

increased pancreatic ductal adenocarcinoma incidence_Cdkn2a<tm4Rdp>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• cyclin-dependent kinase inhibitor 2A
  http://metadb.riken.jp/db/mgi_rdf/MGI:104738
• pancreas specific transcription factor, 1a
  http://metadb.riken.jp/db/mgi_rdf/MGI:1328312
• SMAD family member 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:894293

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cdkn2a<tm4Rdp>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ptf1a<+>|Kras<tm4Tyj>|Smad4<tm1Rdp>|Kras<+>|Cdkn2a<+>|Cdkn2a<tm4Rdp>|Ptf1a<tm1.1(cre)Cvw>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pancreatic ductal adenocarcinoma incidence
  http://purl.obolibrary.org/obo/MP_0009151

文献

http://purl.org/net/cito/citesAsAuthority

• Nabeel. Bardeesy, et.al., Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer., Genes & development, 2006, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/17114584