Nabeel. Bardeesy, et.al., Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer., Genes & development, 2006, 20

http://rdf.ncbi.nlm.nih.gov/pubmed/17114584

Nabeel. Bardeesy, et.al., Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer., Genes & development, 2006, 20

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Smad4<tm1Rdp>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3693621

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased tumor incidence_Cdkn2a<tm4Rdp>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0002020I129FVBNCdkn2atm4RdpCdkn2aKrastm4TyjKrasSmad4tm1RdpSmad4tm1RdpPtf1atm11creCvwPtf1aPtf1aKrastm4TyjSmad4tm1RdpKrasCdkn2aCdkn2atm4RdpPtf1atm11creCvw
• increased tumor incidence_Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0002020I129FVBNKrastm4TyjKrasSmad4tm1RdpSmad4tm1RdpPtf1atm11creCvwPtf1aKrastm4TyjSmad4tm1RdpKrasPtf1aPtf1atm11creCvw
• increased tumor incidence_Cdkn2a<tm4Rdp>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0002020I129SSvEv129S4SvJaeC57BL6CBAFVBNCdkn2atm4RdpCdkn2aKrastm4TyjKrasSmad4tm1RdpSmad4tm1RdpTgPdx1cre891Dam0TgPdx1cre891DamKrastm4TyjKrasSmad4tm1RdpCdkn2aCdkn2atm4Rdp
• increased tumor incidence_Cdkn2a<tm4Rdp>/Cdkn2a<tm4Rdp>,Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0002020I129SSvEv129S4SvJaeC57BL6CBAFVBNCdkn2atm4RdpCdkn2atm4RdpKrastm4TyjKrasSmad4tm1RdpSmad4tm1RdpTgPdx1cre891Dam0Krastm4TyjTgPdx1cre891DamKrasSmad4tm1RdpCdkn2atm4Rdp
• increased tumor incidence_Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0002020I129SSvEv129S4SvJaeC57BL6CBAFVBNKrastm4TyjKrasSmad4tm1RdpSmad4tm1RdpTgPdx1cre891Dam0Krastm4TyjTgPdx1cre891DamSmad4tm1RdpKras
• premature death_Cdkn2a<tm4Rdp>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0002083I129FVBNCdkn2atm4RdpCdkn2aKrastm4TyjKrasSmad4tm1RdpSmad4tm1RdpPtf1atm11creCvwPtf1aPtf1aKrastm4TyjSmad4tm1RdpKrasCdkn2aCdkn2atm4RdpPtf1atm11creCvw
他26件を見る
• premature death_Cdkn2a<tm4Rdp>/Cdkn2a<tm4Rdp>,Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0002083I129FVBNCdkn2atm4RdpCdkn2atm4RdpKrastm4TyjKrasSmad4tm1RdpSmad4tm1RdpPtf1atm11creCvwPtf1aPtf1atm11creCvwCdkn2atm4RdpPtf1aSmad4tm1RdpKrasKrastm4Tyj
• premature death_Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0002083I129FVBNKrastm4TyjKrasSmad4tm1RdpSmad4tm1RdpPtf1atm11creCvwPtf1aKrastm4TyjSmad4tm1RdpKrasPtf1aPtf1atm11creCvw
• premature death_Cdkn2a<tm4Rdp>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0002083I129S1Sv129S4SvJae129X1SvJCdkn2atm4RdpCdkn2aKrastm4TyjKrasPtf1atm11creCvwPtf1aCdkn2aPtf1atm11creCvwCdkn2atm4RdpPtf1aKrasKrastm4Tyj
• premature death_Cdkn2a<tm4Rdp>/Cdkn2a<tm4Rdp>,Kras<tm4Tyj>/Kras<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0002083I129S1Sv129S4SvJae129X1SvJCdkn2atm4RdpCdkn2atm4RdpKrastm4TyjKrasPtf1atm11creCvwPtf1aKrasKrastm4TyjPtf1aPtf1atm11creCvwCdkn2atm4Rdp
• premature death_Cdkn2a<tm4Rdp>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6CBACdkn2atm4RdpCdkn2aKrastm4TyjKrasTgPdx1cre891Dam0KrasTgPdx1cre891DamKrastm4TyjCdkn2atm4RdpCdkn2a
• premature death_Cdkn2a<tm4Rdp>/Cdkn2a<tm4Rdp>,Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6CBAFVBNCdkn2atm4RdpCdkn2atm4RdpKrastm4TyjKrasTgPdx1cre891Dam0Cdkn2atm4RdpKrastm4TyjTgPdx1cre891DamKras
• premature death_Cdkn2a<tm4Rdp>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0002083I129SSvEv129S4SvJaeC57BL6CBAFVBNCdkn2atm4RdpCdkn2aKrastm4TyjKrasSmad4tm1RdpSmad4tm1RdpTgPdx1cre891Dam0TgPdx1cre891DamKrastm4TyjKrasSmad4tm1RdpCdkn2aCdkn2atm4Rdp
• premature death_Cdkn2a<tm4Rdp>/Cdkn2a<tm4Rdp>,Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0002083I129SSvEv129S4SvJaeC57BL6CBAFVBNCdkn2atm4RdpCdkn2atm4RdpKrastm4TyjKrasSmad4tm1RdpSmad4tm1RdpTgPdx1cre891Dam0Krastm4TyjTgPdx1cre891DamKrasSmad4tm1RdpCdkn2atm4Rdp
• premature death_Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0002083I129SSvEv129S4SvJaeC57BL6CBAFVBNKrastm4TyjKrasSmad4tm1RdpSmad4tm1RdpTgPdx1cre891Dam0Krastm4TyjTgPdx1cre891DamSmad4tm1RdpKras
• pancreas cysts_Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0003336I129FVBNKrastm4TyjKrasSmad4tm1RdpSmad4tm1RdpPtf1atm11creCvwPtf1aKrastm4TyjSmad4tm1RdpKrasPtf1aPtf1atm11creCvw
• pancreas cysts_Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0003336I129SSvEv129S4SvJaeC57BL6CBAFVBNKrastm4TyjKrasSmad4tm1RdpSmad4tm1RdpTgPdx1cre891Dam0Krastm4TyjTgPdx1cre891DamSmad4tm1RdpKras
• duodenum polyps_Smad4<tm1Rdp>/Smad4<tm1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0008012I129SSvEvC57BL6CBAFVBNSmad4tm1RdpSmad4tm1RdpTgPdx1cre891Dam0Smad4tm1RdpTgPdx1cre891Dam
• increased pancreatic ductal adenocarcinoma incidence_Cdkn2a<tm4Rdp>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0009151I129FVBNCdkn2atm4RdpCdkn2aKrastm4TyjKrasSmad4tm1RdpSmad4tm1RdpPtf1atm11creCvwPtf1aPtf1aKrastm4TyjSmad4tm1RdpKrasCdkn2aCdkn2atm4RdpPtf1atm11creCvw
• increased pancreatic ductal adenocarcinoma incidence_Cdkn2a<tm4Rdp>/Cdkn2a<tm4Rdp>,Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0009151I129FVBNCdkn2atm4RdpCdkn2atm4RdpKrastm4TyjKrasSmad4tm1RdpSmad4tm1RdpPtf1atm11creCvwPtf1aPtf1atm11creCvwCdkn2atm4RdpPtf1aSmad4tm1RdpKrasKrastm4Tyj
• increased pancreatic ductal adenocarcinoma incidence_Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0009151I129FVBNKrastm4TyjKrasSmad4tm1RdpSmad4tm1RdpPtf1atm11creCvwPtf1aKrastm4TyjSmad4tm1RdpKrasPtf1aPtf1atm11creCvw
• increased pancreatic ductal adenocarcinoma incidence_Cdkn2a<tm4Rdp>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0009151I129S1Sv129S4SvJae129X1SvJCdkn2atm4RdpCdkn2aKrastm4TyjKrasPtf1atm11creCvwPtf1aCdkn2aPtf1atm11creCvwCdkn2atm4RdpPtf1aKrasKrastm4Tyj
• increased pancreatic ductal adenocarcinoma incidence_Cdkn2a<tm4Rdp>/Cdkn2a<tm4Rdp>,Kras<tm4Tyj>/Kras<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0009151I129S1Sv129S4SvJae129X1SvJCdkn2atm4RdpCdkn2atm4RdpKrastm4TyjKrasPtf1atm11creCvwPtf1aKrasKrastm4TyjPtf1aPtf1atm11creCvwCdkn2atm4Rdp
• increased pancreatic ductal adenocarcinoma incidence_Kras<tm4Tyj>/Kras<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>
  http://metadb.riken.jp/0009151I129S1Sv129S4SvJae129X1SvJKrastm4TyjKrasPtf1atm11creCvwPtf1aPtf1aKrasKrastm4TyjPtf1atm11creCvw
• increased pancreatic ductal adenocarcinoma incidence_Cdkn2a<tm4Rdp>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0009151I129S4SvJaeC57BL6CBACdkn2atm4RdpCdkn2aKrastm4TyjKrasTgPdx1cre891Dam0KrasTgPdx1cre891DamKrastm4TyjCdkn2atm4RdpCdkn2a
• increased pancreatic ductal adenocarcinoma incidence_Cdkn2a<tm4Rdp>/Cdkn2a<tm4Rdp>,Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0009151I129S4SvJaeC57BL6CBAFVBNCdkn2atm4RdpCdkn2atm4RdpKrastm4TyjKrasTgPdx1cre891Dam0Cdkn2atm4RdpKrastm4TyjTgPdx1cre891DamKras
• increased pancreatic ductal adenocarcinoma incidence_Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0009151I129S4SvJaeC57BL6CBAKrastm4TyjKrasTgPdx1cre891Dam0TgPdx1cre891DamKrastm4TyjKras
• increased pancreatic ductal adenocarcinoma incidence_Cdkn2a<tm4Rdp>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0009151I129SSvEv129S4SvJaeC57BL6CBAFVBNCdkn2atm4RdpCdkn2aKrastm4TyjKrasSmad4tm1RdpSmad4tm1RdpTgPdx1cre891Dam0TgPdx1cre891DamKrastm4TyjKrasSmad4tm1RdpCdkn2aCdkn2atm4Rdp
• increased pancreatic ductal adenocarcinoma incidence_Cdkn2a<tm4Rdp>/Cdkn2a<tm4Rdp>,Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0009151I129SSvEv129S4SvJaeC57BL6CBAFVBNCdkn2atm4RdpCdkn2atm4RdpKrastm4TyjKrasSmad4tm1RdpSmad4tm1RdpTgPdx1cre891Dam0Krastm4TyjTgPdx1cre891DamKrasSmad4tm1RdpCdkn2atm4Rdp
• increased stomach tumor incidence_Cdkn2a<tm4Rdp>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0010301I129SSvEv129S4SvJaeC57BL6CBAFVBNCdkn2atm4RdpCdkn2aKrastm4TyjKrasSmad4tm1RdpSmad4tm1RdpTgPdx1cre891Dam0TgPdx1cre891DamKrastm4TyjKrasSmad4tm1RdpCdkn2aCdkn2atm4Rdp
• increased stomach tumor incidence_Cdkn2a<tm4Rdp>/Cdkn2a<tm4Rdp>,Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0010301I129SSvEv129S4SvJaeC57BL6CBAFVBNCdkn2atm4RdpCdkn2atm4RdpKrastm4TyjKrasSmad4tm1RdpSmad4tm1RdpTgPdx1cre891Dam0Krastm4TyjTgPdx1cre891DamKrasSmad4tm1RdpCdkn2atm4Rdp
• increased stomach tumor incidence_Kras<tm4Tyj>/Kras<+>,Smad4<tm1Rdp>/Smad4<tm1Rdp>,Tg(Pdx1-cre)89.1Dam/0
  http://metadb.riken.jp/0010301I129SSvEv129S4SvJaeC57BL6CBAFVBNKrastm4TyjKrasSmad4tm1RdpSmad4tm1RdpTgPdx1cre891Dam0Krastm4TyjTgPdx1cre891DamSmad4tm1RdpKras

class

http://purl.org/net/cito/citesAsAuthority

• Smad4<tm1Rdp>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3693621