increased pancreatic ductal adenocarcinoma incidence_Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(tetO-Kras*G12D)#Rdp/0,Trp53<tm1Brn>/Trp53<tm1Brn>

http://metadb.riken.jp/0009151I129P2OlaHsd129S1Sv129X1SvJC57BL6FVBNGtROSA26Sortm1rtTAEGFPNagyGtROSA26SorPtf1atm11creCvwPtf1aTgtetOKrasG12DRdp0Trp53tm1BrnTrp53tm1BrnPtf1atm11creCvwGtROSA26Sortm1rtTAEGFPNagyPtf1aTrp53tm1BrnTgtetOKrasG12DRdpGtROSA26Sor

increased pancreatic ductal adenocarcinoma incidence_Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(tetO-Kras*G12D)#Rdp/0,Trp53<tm1Brn>/Trp53<tm1Brn>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• pancreas specific transcription factor, 1a
  http://metadb.riken.jp/db/mgi_rdf/MGI:1328312
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion, Ronald DePinho
  http://metadb.riken.jp/db/mgi_rdf/MGI:5648529

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(tetO-Kras*G12D)#Rdp/0,Trp53<tm1Brn>/Trp53<tm1Brn>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ptf1a<tm1.1(cre)Cvw>|Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>|Ptf1a<+>|Trp53<tm1Brn>|Tg(tetO-Kras*G12D)#Rdp|Gt(ROSA)26Sor<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pancreatic ductal adenocarcinoma incidence
  http://purl.obolibrary.org/obo/MP_0009151

文献

http://purl.org/net/cito/citesAsAuthority

• Haoqiang. Ying, et.al., Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism., Cell, 2012, 149
  http://rdf.ncbi.nlm.nih.gov/pubmed/22541435